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MM 419447

Product Name
MM 419447
CAS No.
1092457-78-7
Chemical Name
MM 419447
Synonyms
MM 419447;Linaclotide Impurity 4;Linaclotide Impurity 4 Monomer;L-Cysteine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-, cyclic (1→6),(2→10),(5→13)-tris(disulfide)
CBNumber
CB69732371
Molecular Formula
C50H70N14O19S6
Formula Weight
1363.55
MOL File
1092457-78-7.mol
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MM 419447 Property

Boiling point:
1951.7±65.0 °C(Predicted)
Density 
1.60±0.1 g/cm3(Predicted)
solubility 
DMSO : 100 mg/mL (73.34 mM; Need ultrasonic)
form 
Solid
pka
2.96±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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MM 419447 Chemical Properties,Usage,Production

Uses

MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C)[1].

in vivo

MM 419447 (10 mg/kg; p.o.) treatment shows the Cmax, AUC0-6 and t1/2 values of 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively[1]

Animal Model:Female Sprague-Dawley rats[1]
Dosage:10 mg/kg
Administration:P.o. (Pharmacokinetic Analysis)
Result:The Cmax, AUC0-6 and Tmax were 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively.

References

[1] Busby RW, et al. Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. J Pharmacol Exp Ther. 2013;344 DOI:10.1124/jpet.112.199430

MM 419447 Preparation Products And Raw materials

Raw materials

Preparation Products

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MM 419447 Suppliers

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1092457-78-7, MM 419447Related Search:


  • MM 419447
  • L-Cysteine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-, cyclic (1→6),(2→10),(5→13)-tris(disulfide)
  • Linaclotide Impurity 4
  • Linaclotide Impurity 4 Monomer
  • 1092457-78-7