Sunvozertinib

Product Name: Sunvozertinib
CAS No.: 2370013-12-8
Chemical Name: Sunvozertinib
Synonyms: Sunvozertinib;Sunvozertinib, 10 mM in DMSO;N-{5-({4-[5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl}amino)-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl}prop-2-enamide;(R)-N-(5-((4-((5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)phenyl)amino)pyrimidin-2-yl)amino)-2-(3-(dimethylamino)pyrrolidin-1-yl)-4-methoxyphenyl)acrylamide;2-Propenamide, N-[5-[[4-[[5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3R)-3-(dimethylamino)-1-pyrrolidinyl]-4-methoxyphenyl]-
CBNumber: CB69757433
Molecular Formula: C29H35ClFN7O3
Formula Weight: 584.08
MOL File: 2370013-12-8.mol

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Sunvozertinib Property

Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
pka: 12.29±0.70(Predicted)
form: Solid
color: Off-white to light brown
InChIKey: BTMKEDDEMKKSEF-QGZVFWFLSA-N
SMILES: C(NC1=CC(NC2=NC=CC(NC3=CC(Cl)=C(F)C=C3C(O)(C)C)=N2)=C(OC)C=C1N1CC[C@@H](N(C)C)C1)(=O)C=C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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Sunvozertinib Chemical Properties,Usage,Production

Description

Sunvozertinib, also known as DZD9008, is an oral, potent, irreversible, and selective EGFR tyrosine kinase inhibitor. Sunvozertinib shows activity against EGFRexon20ins and other mutations. In both cell lines and xenograft models, sunvozertinib shows potent antitumor activity. In the two ongoing phase I clinical studies, sunvozertinib was tolerated up to 400 mg once daily.

Uses

Sunvozertinib (DZD9008) is a potent ErbBs (EGFR, Her2, especially mutant forms) and BTK inhibitor. Sunvozertinib shows IC50s of 20.4, 20.4, 1.1, 7.5, and 80.4 nM for EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, and Her2 Exon20 YVMA, and EGFR WT A431, respectively (patent WO2019149164A1, example 52)[1].

IC 50

EGFR exon 20 insertion: 20.4 nM (IC₅₀); EGFR^L858R/T790M: 1.1 nM (IC₅₀); Her2 Exon20 YVMA: 7.5 nM (IC₅₀)

References

[1] Zhengtao LI, et al. Erbb/btk inhibitors. WO2019149164A1.

Sunvozertinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Sunvozertinib Suppliers

China 44 Global 44

Jiangsu Magic Biotechnology Co., Ltd

Tel: 13921770081
Email: svp01@magicbiotech.cn
Country: China
ProdList: 500
Advantage: 58

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 18971495150;
Email: sales@sun-shinechem.com
Country: China
ProdList: 1136
Advantage: 64

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 40000
Advantage: 60

Wellman Pharmaceutical Group Limited

Tel: 18971451745 18971451745
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 3649
Advantage: 58

Wuhan Sun-shine Bio-technology Corporation Limited

Tel: +86-027-6552-2453
Email: sales@sun-shinechem.com
Country: China
ProdList: 727
Advantage: 58

SuZhou Medinoah Co.,LTD.

Tel: 0512-69561983 13914027025
Fax: 0512-69561982
Email: zhang_q@medinoah.com
Country: China
ProdList: 3893
Advantage: 58

Shandong utilizing biological technology co., LTD

Tel: 15966937598
Fax: 3407640895 3071519937
Email: 3407650895@qq.com
Country: China
ProdList: 4111
Advantage: 58

Guangzhou Belka Biological Technology Co., Ltd.

Tel: +86-18665676617
Fax: 18665676617
Country: China
ProdList: 957
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: +86-0519-85788828 +86-13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 4032
Advantage: 58

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View Lastest Price from Sunvozertinib manufacturers

Guangzhou Biocar Biotechnology Co.,Ltd.

Product: Sunvozertinib 2370013-12-8
Price: US $399.00-398.00/g
Min. Order: 1g
Purity: 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets，Customized packaging
Supply Ability: 1kg
Release date: 2022-11-04

2370013-12-8, SunvozertinibRelated Search:

2-Propenamide, N-[5-[[4-[[5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3R)-3-(dimethylamino)-1-pyrrolidinyl]-4-methoxyphenyl]-

Sunvozertinib

(R)-N-(5-((4-((5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)phenyl)amino)pyrimidin-2-yl)amino)-2-(3-(dimethylamino)pyrrolidin-1-yl)-4-methoxyphenyl)acrylamide

Sunvozertinib, 10 mM in DMSO

N-{5-({4-[5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl}amino)-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl}prop-2-enamide

2370013-12-8