Sunvozertinib

Product Name: Sunvozertinib
CAS No.: 2370013-12-8
Chemical Name: Sunvozertinib
Synonyms: Sunvozertinib;Sunvozertinib, 10 mM in DMSO;N-{5-({4-[5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl}amino)-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl}prop-2-enamide;(R)-N-(5-((4-((5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)phenyl)amino)pyrimidin-2-yl)amino)-2-(3-(dimethylamino)pyrrolidin-1-yl)-4-methoxyphenyl)acrylamide;2-Propenamide, N-[5-[[4-[[5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3R)-3-(dimethylamino)-1-pyrrolidinyl]-4-methoxyphenyl]-
CBNumber: CB69757433
Molecular Formula: C29H35ClFN7O3
Formula Weight: 584.08
MOL File: 2370013-12-8.mol

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Sunvozertinib Property

Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
pka: 12.29±0.70(Predicted)
form: Solid
color: Off-white to light brown
InChIKey: BTMKEDDEMKKSEF-QGZVFWFLSA-N
SMILES: C(NC1=CC(NC2=NC=CC(NC3=CC(Cl)=C(F)C=C3C(O)(C)C)=N2)=C(OC)C=C1N1CC[C@@H](N(C)C)C1)(=O)C=C

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Hazard and Precautionary Statements (GHS)

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Sunvozertinib Chemical Properties,Usage,Production

Description

Sunvozertinib, also known as DZD9008, is an oral, potent, irreversible, and selective EGFR tyrosine kinase inhibitor. Sunvozertinib shows activity against EGFRexon20ins and other mutations. In both cell lines and xenograft models, sunvozertinib shows potent antitumor activity. In the two ongoing phase I clinical studies, sunvozertinib was tolerated up to 400 mg once daily.

Uses

Sunvozertinib (DZD9008) is a potent ErbBs (EGFR, Her2, especially mutant forms) and BTK inhibitor. Sunvozertinib shows IC50s of 20.4, 20.4, 1.1, 7.5, and 80.4 nM for EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, and Her2 Exon20 YVMA, and EGFR WT A431, respectively (patent WO2019149164A1, example 52)[1].

IC 50

EGFR exon 20 insertion: 20.4 nM (IC₅₀); EGFR^L858R/T790M: 1.1 nM (IC₅₀); Her2 Exon20 YVMA: 7.5 nM (IC₅₀)

References

[1] Zhengtao LI, et al. Erbb/btk inhibitors. WO2019149164A1.

Sunvozertinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Sunvozertinib Suppliers

China 42 Global 42

Jiangsu Magic Biotechnology Co., Ltd

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Wellman Pharmaceutical Group Limited

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View Lastest Price from Sunvozertinib manufacturers

Guangzhou Biocar Biotechnology Co.,Ltd.

Product: Sunvozertinib 2370013-12-8
Price: US $399.00-398.00/g
Min. Order: 1g
Purity: 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets，Customized packaging
Supply Ability: 1kg
Release date: 2022-11-04

2370013-12-8, SunvozertinibRelated Search:

2-Propenamide, N-[5-[[4-[[5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3R)-3-(dimethylamino)-1-pyrrolidinyl]-4-methoxyphenyl]-

Sunvozertinib

(R)-N-(5-((4-((5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)phenyl)amino)pyrimidin-2-yl)amino)-2-(3-(dimethylamino)pyrrolidin-1-yl)-4-methoxyphenyl)acrylamide

Sunvozertinib, 10 mM in DMSO

N-{5-({4-[5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl}amino)-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl}prop-2-enamide

2370013-12-8