ChemicalBook > CAS DataBase List > 1H-Indole-2-carboxamide, 4-fluoro-7-methyl-N-[(1R,3S)-3-[(3S)-3-[methyl(methylsulfonyl)amino]-1-pyrrolidinyl]cyclohexyl]-
1H-Indole-2-carboxamide, 4-fluoro-7-methyl-N-[(1R,3S)-3-[(3S)-3-[methyl(methylsulfonyl)amino]-1-pyrrolidinyl]cyclohexyl]-
- Product Name
- 1H-Indole-2-carboxamide, 4-fluoro-7-methyl-N-[(1R,3S)-3-[(3S)-3-[methyl(methylsulfonyl)amino]-1-pyrrolidinyl]cyclohexyl]-
- CAS No.
- 2697176-16-0
- Chemical Name
- 1H-Indole-2-carboxamide, 4-fluoro-7-methyl-N-[(1R,3S)-3-[(3S)-3-[methyl(methylsulfonyl)amino]-1-pyrrolidinyl]cyclohexyl]-
- Synonyms
- 1H-Indole-2-carboxamide, 4-fluoro-7-methyl-N-[(1R,3S)-3-[(3S)-3-[methyl(methylsulfonyl)amino]-1-pyrrolidinyl]cyclohexyl]-
- CBNumber
- CB69925559
- Molecular Formula
- C22H31FN4O3S
- Formula Weight
- 450.57
- MOL File
- 2697176-16-0.mol
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1H-Indole-2-carboxamide, 4-fluoro-7-methyl-N-[(1R,3S)-3-[(3S)-3-[methyl(methylsulfonyl)amino]-1-pyrrolidinyl]cyclohexyl]- Property
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 2 mg/mL, clear
- form
- Solid
- pka
- 14.79±0.40(Predicted)
- color
- Off-white to yellow
- SMILES
- FC1=C2C(NC(C(N[C@H]3C[C@@H](N4C[C@H](CC4)N(C)S(C)(=O)=O)CCC3)=O)=C2)=C(C=C1)C.[0.75H2O]
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
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N-Bromosuccinimide Price
DC Chemicals
- Product number
- DC47616
- Product name
- EPZ-719
- Purity
- >98%
- Packaging
- 5mg
- Price
- $750
- Updated
- 2026/05/24
DC Chemicals
- Product number
- DC47616
- Product name
- EPZ-719
- Packaging
- 10mg
- Price
- $1100
- Updated
- 2026/05/24
DC Chemicals
- Product number
- DC47616
- Product name
- EPZ-719
- Packaging
- 25mg
- Price
- $1800
- Updated
- 2026/05/24
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1H-Indole-2-carboxamide, 4-fluoro-7-methyl-N-[(1R,3S)-3-[(3S)-3-[methyl(methylsulfonyl)amino]-1-pyrrolidinyl]cyclohexyl]- Chemical Properties,Usage,Production
Biological Activity
EPZ-719 is a novel and potent SETD2 inhibitor ( IC50 = 0.005 μM) with a high selectivity over other histone methyltransferases.
References
[1]. Lampe JW, et al. Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies. ACS Med Chem Lett. 2021 Aug 24;12(10):1539-1545.
1H-Indole-2-carboxamide, 4-fluoro-7-methyl-N-[(1R,3S)-3-[(3S)-3-[methyl(methylsulfonyl)amino]-1-pyrrolidinyl]cyclohexyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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1H-Indole-2-carboxamide, 4-fluoro-7-methyl-N-[(1R,3S)-3-[(3S)-3-[methyl(methylsulfonyl)amino]-1-pyrrolidinyl]cyclohexyl]- Suppliers
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