ZLc002
- Product Name
- ZLc002
- CAS No.
- 308277-46-5
- Chemical Name
- ZLc002
- Synonyms
- ZLc002;EX-A5758;(S)-ZLc002;EX A5758,EXA5758;Methyl (3-methoxy-3-oxopropanoyl)-L-valinate;L-Valine, N-(3-methoxy-1,3-dioxopropyl)-, methyl ester
- CBNumber
- CB69933477
- Molecular Formula
- C10H17NO5
- Formula Weight
- 231.25
- MOL File
- 308277-46-5.mol
ZLc002 Property
- Boiling point:
- 350.1±22.0 °C(Predicted)
- Density
- 1.115±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 46 mg/mL (198.92 mM);Ethanol: 46 mg/mL (198.92 mM)
- pka
- 12.22±0.46(Predicted)
- form
- Solid
- color
- Off-white to light yellow
- Water Solubility
- Water: 46 mg/mL (198.92 mM)
- InChI
- InChI=1S/C10H17NO5/c1-6(2)9(10(14)16-4)11-7(12)5-8(13)15-3/h6,9H,5H2,1-4H3,(H,11,12)/t9-/m0/s1
- InChIKey
- BWPKYDAJBOUZDX-VIFPVBQESA-N
- SMILES
- C(OC)(=O)[C@H](C(C)C)NC(=O)CC(OC)=O
ZLc002 Chemical Properties,Usage,Production
Biological Activity
ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain.
Biological Functions
ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability. It could disrupt binding between nNOS and NOS1AP using ex-vivo, in vitro, and purified recombinant systems. In vitro, ZLc002 reduced coimmunoprecipitation of full-length NOS1AP and nNOS in cultured neurons and HEK293T cells co-expressing full-length nNOS and NOS1AP[1].
References
[1] Lee WH, et al. Mol Pain. 2018 Jan-Dec;14:1744806918801224.
[2] Wan-Hung Lee. “ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability.” Molecular Pain 14 (2018): 1744806918801224.
ZLc002 Preparation Products And Raw materials
Raw materials
Preparation Products
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