7-ETHYLISATIN
- Product Name
- 7-ETHYLISATIN
- CAS No.
- 79183-65-6
- Chemical Name
- 7-ETHYLISATIN
- Synonyms
- NSC61828;ALD-N000069;7-Ethylisatin;7-Ethylindoline-2,3-dione;7-Ethyl-1H-indol-2,3-dione;7-Ethyl-1H-indole-2,3-dione;1H-Indole-2,3-dione,7-ethyl-;7-Ethyl-1H-indole-2,3-dione >98%;7-ethyl-2,3-dihydro-1H-indole-2,3-dione;7-ethyl-1H-indole-2,3-dione(SALTDATA: FREE)
- CBNumber
- CB71010946
- Molecular Formula
- C10H9NO2
- Formula Weight
- 175.18
- MOL File
- 79183-65-6.mol
7-ETHYLISATIN Property
- Melting point:
- 193 °C(Solv: ethanol (64-17-5))
- Density
- 1.247±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 9.86±0.20(Predicted)
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E702963
- Product name
- 7-Ethyl-1H-indole-2,3-dione
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 030124
- Product name
- 7-Ethyl-1H-indole-2,3-dione
- Packaging
- 500mg
- Price
- $174
- Updated
- 2021/12/16
- Product number
- W8484
- Product name
- 7-Ethylindoline-2,3-dione
- Packaging
- 1g
- Price
- $208
- Updated
- 2021/12/16
- Product number
- OR952606
- Product name
- 7-Ethylisatin
- Purity
- 95%
- Packaging
- 1g
- Price
- $211
- Updated
- 2021/12/16
- Product number
- CHM0013207
- Product name
- 7-ETHYL-1H-INDOLE-2,3-DIONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $220.5
- Updated
- 2021/12/16
7-ETHYLISATIN Chemical Properties,Usage,Production
Uses
7-Ethyl-1H-indole-2,3-dione is used in the synthetic preparation of substituted indolin-2-ones as p90 ribosomal s6 protein kinase 2 (RSK2) inhibitors.
Synthesis
7509-61-7
79183-65-6
Intermediate 62 was ground as described by Yang et al. (see J. Am. Chem. Soc., 1996, 118:9557) and added in portions to a 50 mL conical flask containing 15 mL of concentrated sulfuric acid while maintaining stirring and maintaining the temperature at 90°C. Acetamide was added slowly, ensuring that the temperature of the reaction mixture did not exceed 105 °C. After addition, the purple-black solution was continued to be stirred at 90°C for 15 minutes, subsequently cooled to 60°C and poured into a beaker containing 15 g of crushed ice. Ice was continued to be added until the outside of the beaker was cold to the touch. The orange-brown precipitate was collected by filtration and dried overnight under vacuum to afford dihydroindole-2,3-dione (Intermediate 63, 0.77 g, 27% yield) of sufficient purity for use in the next step. Intermediate 63 was also recrystallized from ethanol to give a pure orange-red needle product.1H NMR (400 MHz, DMSO-d6) δ 1.14 (t, J = 7.5 Hz, 3H), 2.56 (q, J = 7.6 Hz, 2H), 7.03 (t, J = 7.5 Hz, 1H), 7.35 (d, J = 7.3 Hz, 1H), 7.46 (d , J = 7.6 Hz, 1H), 11.11 (s, 1H).
References
[1] Bulletin of the Chemical Society of Japan, 2006, vol. 79, # 10, p. 1585 - 1600
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002, vol. 41, # 3, p. 628 - 630
[3] Patent: US2008/255192, 2008, A1. Location in patent: Page/Page column 22-23
[4] Journal of Medicinal Chemistry, 2010, vol. 53, # 16, p. 6003 - 6017
[5] Journal of Organic Chemistry, 2018, vol. 83, # 15, p. 7622 - 7632
7-ETHYLISATIN Preparation Products And Raw materials
Raw materials
Preparation Products
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