SR 31747
- Product Name
- SR 31747
- CAS No.
- 132173-07-0
- Chemical Name
- SR 31747
- Synonyms
- SR 31747;SR 31747,SR31747;HKHPCMBPASXYGP-KVVVOXFISA-N;(Z)-N-(3-(3-Chloro-4-cyclohexylphenyl)allyl)-N-ethylcyclohexanamine;3-(3-Chloro-4-cyclohexylphenyl)-N-cyclohexyl-N-ethyl-2(Z)-propenylaMine;(Z)-N-(3-(3-Chloro-4-cyclohexylphenyl)allyl)-N-ethylcyclohexanamine hydrochloride;3-(3-Chloro-4-cyclohexylphenyl)-N-cyclohexyl-N-ethyl-2(Z)-propenylaMine hydrochloride;(Z)-N-[3-(3-CHLORO-4-CYCLOHEXYLPHENYL)PROP-2-ENYL]-N-ETHYLCYCLOHEXYLAMINE HYDROCHLORIDE
- CBNumber
- CB71011640
- Formula Weight
- 0
- MOL File
- 132173-07-0.mol
SR 31747 Property
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-0007776
- Product name
- SR-31747
- Purity
- 99.80%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0007776
- Product name
- SR-31747
- Purity
- 99.80%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0007776
- Product name
- SR-31747
- Purity
- 99.80%
- Packaging
- 100mg
- Price
- $2250
- Updated
- 2021/12/16
SR 31747 Chemical Properties,Usage,Production
Uses
SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase[1][2].
in vivo
In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6 and TNF-α in a dose-dependent manner (ED50, 2 mg/kg). SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. This conclusion was supported by in vivo experiments that shows that: 1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747; 2) administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition[1].
References
[1] Derocq JM, et al. In vivo inhibition of endotoxin-induced pro-inflammatory cytokines production by the sigma ligand SR 31747. J Pharmacol Exp Ther. 1995 Jan;272(1):224-30. PMID:7815336
[2] Silve S, et al. The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae. Mol Cell Biol. 1996 Jun;16(6):2719-27. DOI:10.1128/MCB.16.6.2719
SR 31747 Preparation Products And Raw materials
Raw materials
Preparation Products
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