ChemicalBook > CAS DataBase List > (R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL

(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL

Product Name
(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL
CAS No.
139290-65-6
Chemical Name
(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL
Synonyms
M 100907;MDL100907;R-MDL 100907;VOLINANSERIN;MDL 100907 NEW;MDL100907-L-tartrate;MDL100907 tartrate salt;MDL 100907 (MDL-100907;MDL-100907(Volinanserin);Volinanserin (MDL100907)
CBNumber
CB7103504
Molecular Formula
C22H28FNO3
Formula Weight
373.46
MOL File
139290-65-6.mol
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(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL Property

Melting point:
89-91°C
Boiling point:
499.4±45.0 °C(Predicted)
Density 
1.150±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥20mg/mL
pka
13.93±0.20(Predicted)
form 
powder
color 
off-white to light brown
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Safety

Hazard Codes 
N
Risk Statements 
50
Safety Statements 
61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M3324
Product name
M100907
Purity
≥98% (HPLC)
Packaging
5mg
Price
$165
Updated
2024/03/01
Sigma-Aldrich
Product number
M3324
Product name
M100907
Purity
≥98% (HPLC)
Packaging
25mg
Price
$693
Updated
2024/03/01
Cayman Chemical
Product number
15936
Product name
Volinanserin
Purity
≥95%
Packaging
1mg
Price
$55
Updated
2024/03/01
Cayman Chemical
Product number
15936
Product name
Volinanserin
Purity
≥95%
Packaging
5mg
Price
$144
Updated
2024/03/01
Cayman Chemical
Product number
15936
Product name
Volinanserin
Purity
≥95%
Packaging
10mg
Price
$263
Updated
2024/03/01
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(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL Chemical Properties,Usage,Production

Description

Volinanserin is a potent and selective antagonist of the serotonin receptor 5-HT2A (Ki = 0.36-0.85 nM). It weakly binds 5-HT2C, α1-adrenergic, and sigma receptors (Ki = 88, 128, and 87 nM) and much less effectively associates with other serotonin, dopamine, adrenergic, muscarinic acetylcholine receptors and monoamine transporters. Volinanserin displays antipsychotic activity, attenuates impulsivity, and augments antidepressant effects in vivo.

Chemical Properties

Colourless solid

Uses

Volinanserin is a serotonin receptor 5-HT2A antagonist; anti-psychotic.

Uses

As a serotonin 5-HT2A receptor antagonist, Volinanserin Hydrochloride Salt can be used as potential controls in various biological studies.

General Description

M100907 blocks the serotonin 2A (5-HT2A) receptors and imposes antidepressant-like effects. It may be used for treating dopaminergic anomalies.

Biochem/physiol Actions

M100907 is a selective 5-HT2A Antagonist.

storage

+4°C

(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL Suppliers

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139290-65-6, (R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOLRelated Search:

4-(3-METHOXY-BENZYL)-PIPERIDINE ALPHA-PHENYL-1-(2-PHENYLETHYL)-4-PIPERIDINEMETHANOL CHEMBRDG-BB 4010734 4-(2-METHOXY-BENZYL)-PIPERIDINE 3-PIPERIDIN-4-YLMETHYL-PHENOL PHENYL-PIPERIDIN-4-YL-METHANOL (R)-(+)-ALPHA-(3-HYDROXY-2-METHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL (+/-)-ALPHA-(2,3-DIMETHOXY-PHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINE-METHANOL Volinanserin Hydrochloride Salt

  • (+)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
  • (aR)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
  • M 100907
  • R-MDL 100907
  • (R)-(+)-(-(2,3-Dimethoxyphenyl)-1-[2-(4-fluoro-phenyl)ethyl]-4-piperidine methanol (R,R)-tartrate
  • 4-Piperidinemethanol, 1-[2-(4-fluorophenyl)ethyl]-(-(2,3-dimethoxyphenyl)-, ((R), (R,R)-tartrate
  • MDL100907-L-tartrate
  • (R)-(+)-(-(2,3-Dimethoxyphenyl)-1-[2-(4-fluoro-phenyl)ethyl]-4-piperidine methanol
  • 4-Piperidinemethanol, 1-[2-(4-fluorophenyl)ethyl]-(-(2,3-dimethoxyphenyl)-, ((R)
  • MDL100907 tartrate salt
  • (+)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol Hydrochloride
  • (aR)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol Hydrochloride
  • Volinanserin Hydrochloride Salt
  • (+)-α-(2,3-DiMethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidineMethanol Hydrochloride
  • (αR)-α-(2,3-DiMethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidineMethanol Hydrochloride
  • MDL-100907(Volinanserin)
  • (R)-(+)-a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol
  • (R)-(2,3-dimethoxyphenyl)(1-(4-fluorophenethyl)piperidin-4-yl)methanol
  • 4-piperidinemethanol, a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-, (ar)-
  • MDL100907
  • 4-PIPERIDINEMETHANOL, 1-[2-(4-FLUOROPHENYL)ETHYL]-ALPHA-(2,3-DIMETHOXYPHENYL)-, (ALPHAR)
  • (R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL
  • VOLINANSERIN
  • (R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol
  • MDL 100907 (MDL-100907
  • MDL 100907 NEW
  • Volinanserin (MDL100907)
  • Serotonin Receptor,inhibit,MDL 100907,5-HT Receptor,M-100907,5-hydroxytryptamine Receptor,Inhibitor,Volinanserin,M100907,MDL-100907
  • 4-Piperidinemethanol, α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-, (αR)-
  • 139290-65-6
  • C22H29ClFNO3
  • C22H28FNO3C4H6O6
  • C22H28FNO3
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals