Acetamide, N-2-pyrimidinyl- (8CI,9CI)
- Product Name
- Acetamide, N-2-pyrimidinyl- (8CI,9CI)
- CAS No.
- 13053-88-8
- Chemical Name
- Acetamide, N-2-pyrimidinyl- (8CI,9CI)
- Synonyms
- 2-acetylaminopyrimidine;N-(PyriMidin-2-yl)acetaMide;Acetamide, N-2-pyrimidinyl-;Acetamide, N-2-pyrimidinyl- (8CI,9CI)
- CBNumber
- CB71056021
- Molecular Formula
- C6H7N3O
- Formula Weight
- 137.14
- MOL File
- 13053-88-8.mol
Acetamide, N-2-pyrimidinyl- (8CI,9CI) Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B400643
- Product name
- 2-Acetamidopyrimidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 6645BA
- Product name
- n-(Pyrimidin-2-yl)acetamide
- Packaging
- 5g
- Price
- $124
- Updated
- 2021/12/16
- Product number
- CHM0162389
- Product name
- 2-ACETAMIDOPYRIMIDINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $653.07
- Updated
- 2021/12/16
- Product number
- CHM0162389
- Product name
- 2-ACETAMIDOPYRIMIDINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $955.42
- Updated
- 2021/12/16
- Product number
- CHM0162389
- Product name
- 2-ACETAMIDOPYRIMIDINE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1382.48
- Updated
- 2021/12/16
Acetamide, N-2-pyrimidinyl- (8CI,9CI) Chemical Properties,Usage,Production
Synthesis
60-35-5
1722-12-9
13053-88-8
The general procedure for the synthesis of 2-acetylaminopyrimidine from acetamide and 2-chloropyrimidine was as follows: to a screw-capped vial were added acetamide (121 mg, 1.00 mmol), Cs2CO3 (456 mg, 1.40 mmol), Xantphos (87 mg, 0.15 mmol), Pd2(dba)3 (46 mg, 0.050 mmol ), 2-chloropyrimidine (137 mg, 1.20 mmol), and 1,4-dioxane (2 mL). The reaction mixture was deoxygenated by nitrogen bubbling for 3 min, followed by stirring the reaction for 16 h at 100 °C. After completion of the reaction, the mixture was cooled to room temperature. The reaction mixture was diluted with dichloromethane and filtered through a diatomaceous earth pad to remove insoluble impurities. The filtrate was concentrated under reduced pressure to remove the solvent to give the crude product. The crude product was purified by rapid chromatography on silica gel (eluent: 40-100% ethyl acetate/hexane gradient) to give 2-acetylaminopyrimidine (188 mg, 0.85 mmol, 94% yield) as an amorphous solid.
References
[1] Tetrahedron Letters, 2011, vol. 52, # 9, p. 1020 - 1022
Acetamide, N-2-pyrimidinyl- (8CI,9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
Acetamide, N-2-pyrimidinyl- (8CI,9CI) Suppliers
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