ChemicalBook > CAS DataBase List >  2,4-Dimethoxypyridine

2,4-Dimethoxypyridine

Product Name
2,4-Dimethoxypyridine
CAS No.
18677-43-5
Chemical Name
2,4-Dimethoxypyridine
Synonyms
dihexyllead;2,4-Dimthoxypyridine;2,4-DIMETHOXYPYRIDINE;2,4-DimethoxypyridineI;Pyridine, 2,4-dimethoxy-;2,4-Dimethoxypyridine,>98%
CBNumber
CB7105836
Molecular Formula
C7H9NO2
Formula Weight
139.15
MOL File
18677-43-5.mol
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2,4-Dimethoxypyridine Property

Boiling point:
200-201 °C
Density 
1.064±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
4.71±0.10(Predicted)
Appearance
Colorless to light yellow Liquid
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D460078
Product name
2,4-DimethoxypyridineI
Packaging
10mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
OR901626
Product name
2,4-Dimethoxypyridine
Purity
98%
Packaging
1g
Price
$102
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD53612
Product name
2,4-Dimethoxypyridine
Packaging
1g
Price
$70
Updated
2021/12/16
Matrix Scientific
Product number
089424
Product name
2,4-Dimethoxypyridine
Packaging
1g
Price
$80
Updated
2021/12/16
Matrix Scientific
Product number
089424
Product name
2,4-Dimethoxypyridine
Packaging
5g
Price
$198
Updated
2021/12/16
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2,4-Dimethoxypyridine Chemical Properties,Usage,Production

Uses

2,4-Dimethoxypyridine is mainly used as an organic synthesis intermediate for the synthesis of drug compounds such as PI3K inhibitors and has potential applications in anti-tumor therapy.

Synthesis

26452-80-2

124-41-4

18677-43-5

General procedure for the synthesis of 2,4-dimethoxypyridine from 2,4-dichloropyridine and sodium methanol: Freshly prepared sodium methanol (24 g, 0.44 mol) was added to an anhydrous N-methyl-2-pyrrolidinone (80 mL) solution of 2,4-dichloropyridine (15 g, 0.10 mol). The reaction mixture was stirred at 120 °C for 6 hours. After completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate (800 mL) and washed with water. The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated to give 2,4-dimethoxypyridine (4) as a colorless oil which was pure enough to be used in the next step. Yield: 11.2 g (80%).1H NMR (400 MHz, DMSO-d6): δ 3.80 (s, 3H), 3.84 (s, 3H), 6.33 (d, J = 2.0 Hz, 1H), 6.60 (dd, J = 2.0 Hz, J = 5.6 Hz, 1H), 7.97 (d, J = 5.6 Hz, 1H); 13C NMR (100 MHz, DMSO-d6): δ 167.5, 165.4, 147.4, 106.1, 93.8, 55.3, 53.1; HRMS (ESI) m/z calcd for C7H10NO2 [M+H]+: 140.0706; found: 140.0707.

References

[1] Xiaolin Li. “A Convenient Synthesis of Gimeracil.” Journal of Chemical Research-s 384 1 (2018): 33–34.
[2] Lucas Robke . “Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors.” Tetrahedron 74 35 (2018): Pages 4531-4537.

2,4-Dimethoxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Dimethoxypyridine Suppliers

China 74 Germany 1 India 1 The Netherlands 1 United Kingdom 4 United States 11 Global 92
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View Lastest Price from 2,4-Dimethoxypyridine manufacturers

Career Henan Chemical Co
Product
2,4-DIMETHOXYPYRIDINE 18677-43-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-13

18677-43-5, 2,4-DimethoxypyridineRelated Search:

2-(4-METHOXY-2,3-DIHYDRO-FURO[2,3-B]QUINOLIN-2-YL)-PROPANE-1,2-DIOL 3,5-DIAMINO-2,6-DIMETHOXYPYRIDINE, DIHYDROCHLORIDE SPECIALITY CHEMICALS 2-Methylsulfony-4,5-Dimethoxypyridine,2-METHYLSULFONY-4,6-DIMETHOXYPYRIDINE 3-Bromo-2,6-dimethoxypyridine 2,6-dimethoxypyridine-3-carboxylic acid,2,6-Dimethoxypyridine-3-carboxylic 2-METHYLSULFONY-4,6-DIMETHOXYPYRIDINE 2,6-Dimethoxypyridine-3-amine 2-HYDROXYMETHYL-3,4-DIMETHOXYPYRIDINE Pyridine,3,4-dimethoxy-(9CI) 2,6-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE 2,6-Dimethoxypyridine, 98+%,2,6-DIMETHOXYPYRIDINE 2,6-DIMETHOXYPYRIDINE-5-BORONIC ACID, PINACOL ESTER,2,6-DIMETHOXYPYRIDINE-3-BORONIC ACID PINACOL ESTER 2,3-DIMETHOXYPYRIDINE 2-Chloromethyl-3,4-dimethoxypyridine,Hydrochloride Salt 3-AMINO-2,6-DIMETHOXYPYRIDINE MONOHYDROCHLORIDE 95%,3-Amino-2,6-dimethoxypyridine hydrochloride,3-AMINO-2,6-DIMETHOXYPYRIDINE MONOHYDROCHLORIDE 3,5-Dimethoxypyridine 2,6-Dimethoxypyridine-3-Boroni,2,6-DIMETHOXYPYRIDINE-3-BORONIC ACID,2,6-DIMETHOXYPYRIDINE-5-BORONIC ACID 3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE

  • 2,4-DIMETHOXYPYRIDINE
  • dihexyllead
  • 2,4-Dimethoxypyridine,>98%
  • Pyridine, 2,4-dimethoxy-
  • 2,4-DimethoxypyridineI
  • 2,4-Dimthoxypyridine
  • 18677-43-5
  • Pyridines