Ethanamine, 2-(3-pyridinyloxy)- (9CI)

Ethanamine, 2-(3-pyridinyloxy)- (9CI) Property

Boiling point:

258.8±20.0 °C(Predicted)

Density 

1.089±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

pka

8.08±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

InChI

InChI=1S/C7H10N2O/c8-3-5-10-7-2-1-4-9-6-7/h1-2,4,6H,3,5,8H2

InChIKey

WKMLARMIRUVDDF-UHFFFAOYSA-N

SMILES

C(N)COC1=CC=CN=C1

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

Ethanamine, 2-(3-pyridinyloxy)- (9CI) Chemical Properties,Usage,Production

Synthesis

General procedure for the synthesis of 3-(2-aminoethoxy)pyridine using 2-(pyridin-3-yloxy)acetonitrile (CAS: 266348-17-8) as starting material: 2-(pyridin-3-yloxy)acetonitrile (100 mg, 0.75 mmol), K2CO3 (103 mg, 0.75 mmol), DMSO was sequentially added in a 100 mL two-neck flask (0.1 mL) and H2O (2 mL). The reaction system was placed in an ice bath and 30% H2O2 (0.1 mL) was added slowly and dropwise. Subsequently, the reaction mixture was stirred at room temperature for 5 min, after which the solvent was removed by evaporation. The crude product was purified by column chromatography using ethyl acetate as eluent to give the final white solid product 3-(2-aminoethoxy)pyridine (62.2 mg, 55% yield).

References

[1] Patent: TWI607995, 2017, B. Location in patent: Page/Page column 183