1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]-

Product Name: 1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]-
CAS No.: 1824637-41-3
Chemical Name: 1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]-
Synonyms: VY-3-135, 10 mM in DMSO;orally active,VY3135,Inhibitor,inhibit,VY 3 135,breast cancer,stable ACSS2 inhibitor;3-ethyl-2-[hydroxy(diphenyl)methyl]-N-[(2R)-2-hydroxypropyl]-5-benzimidazolecarboxamide;1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]-;(R)-1-Ethyl-2-(hydroxydiphenylmethyl)-N-(2-hydroxypropyl)-1H-benzo[d]imidazole-6-carboxamide
CBNumber: CB710673622
Molecular Formula: C26H27N3O3
Formula Weight: 429.51
MOL File: 1824637-41-3.mol

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1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]- Property

Boiling point:: 742.8±60.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 100 mg/mL (232.82 mM; Need ultrasonic)
pka: 12.08±0.29(Predicted)
form: Solid
color: White to light yellow
InChIKey: KTPYOTKTDCLZHR-GOSISDBHSA-N
SMILES: C1(C(O)(C2=CC=CC=C2)C2=CC=CC=C2)N(CC)C2=CC(C(NC[C@H](O)C)=O)=CC=C2N=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 43558
Product name: VY-3-135
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2026/04/30

Cayman Chemical

Product number: 43558
Product name: VY-3-135
Purity: ≥98%
Packaging: 5mg
Price: $104
Updated: 2026/04/30

Cayman Chemical

Product number: 43558
Product name: VY-3-135
Purity: ≥98%
Packaging: 10mg
Price: $192
Updated: 2026/04/30

Cayman Chemical

Product number: 43558
Product name: VY-3-135
Purity: ≥98%
Packaging: 25mg
Price: $400
Updated: 2026/04/30

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1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]- Chemical Properties,Usage,Production

Uses

VY-3-135 is a potent, orally active, and stable ACSS2 inhibitor with an IC50 value of 44 nM. VY-3-135 is specific to ACSS2 among the AcCoA synthetase family of enzymes. VY-3-135 does not inhibit ACSS1 or ACSS3 enzymatic activity. VY-3-135 can be used for the research of breast cancer[1].

Biological Activity

VY-3-135 is a potent, orally active, and stable ACSS2 inhibitor with an IC50 value of 44 nM. VY-3-135 is specific to ACSS2 among the AcCoA synthetase family of enzymes. VY-3-135 does not inhibit ACSS1 or ACSS3 enzymatic activity. VY-3-135 can be used for the research of breast cancer[1]. VY-3-135 (0.1, 1 μM; for 24 hours) blocks acetate dependent labeling of palmitate by 13C2-acetate in ACSS2low A7C11 and ACSS2high Brpkp110 cells[1]. VY-3-135 (100 mg/kg/day; PO; 30 days) represses MDA-MB-468 (ACSS2high) tumor growth but is mostly ineffective at blocking WHIM12 (ACSS2low) growth[1].

in vivo

VY-3-135 (100 mg/kg/day; PO; 30 days) represses MDA-MB-468 (ACSS2^high) tumor growth but is mostly ineffective at blocking WHIM12 (ACSS2^low) growth^[1].

References

[1]. Katelyn D Miller, et al. Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth. Cancer Res. 2021 Mar 1;81(5):1252-1264.

1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]- Suppliers

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1824637-41-3, 1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]-Related Search:

1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]-

orally active,VY3135,Inhibitor,inhibit,VY 3 135,breast cancer,stable ACSS2 inhibitor

3-ethyl-2-[hydroxy(diphenyl)methyl]-N-[(2R)-2-hydroxypropyl]-5-benzimidazolecarboxamide

(R)-1-Ethyl-2-(hydroxydiphenylmethyl)-N-(2-hydroxypropyl)-1H-benzo[d]imidazole-6-carboxamide

VY-3-135, 10 mM in DMSO

1824637-41-3