ChemicalBook > CAS DataBase List > Fananserin

Fananserin

Product Name: Fananserin
CAS No.: 127625-29-0
Chemical Name: Fananserin
Synonyms: RP-62203;Fananserin;Fananserin, 10 mM in DMSO;2-[3-[4-(4-Fluorophenyl)piperazino]propyl]-2H-naphth[1,8-cd]isothiazole 1,1-dioxide;2-(3-(4-(4-fluorophenyl)piperazin-1-yl)propyl)-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide;2-[3-[4-(4-Fluorophenyl)-1-piperazinyl]propyl]-2H-naphthyl[1,8-cd]isothiazole-1,1-dioxide;2H-Naphth[1,8-cd]isothiazole, 2-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-, 1,1-dioxide;Fananserin,Inhibitor,5-HT Receptor,inhibit,5-HT2,RP62203,RP-62203,dopamine,Dopamine Receptor,Serotonin Receptor,5-hydroxytryptamine Receptor
CBNumber: CB71073778
Molecular Formula: C23H24FN3O2S
Formula Weight: 425.52
MOL File: 127625-29-0.mol

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Fananserin Property

Melting point:: 95-97 °C(Solv: acetonitrile (75-05-8))
Boiling point:: 641.1±65.0 °C(Predicted)
Density: 1.331±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: Soluble to 100 mM in DMSO
form: Powder
pka: 7.31±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2645
Product name: Fananserin
Purity: ≥99%(HPLC)
Packaging: 10
Price: $155
Updated: 2021/12/16

Tocris

Product number: 2645
Product name: Fananserin
Purity: ≥99%(HPLC)
Packaging: 50
Price: $558
Updated: 2021/12/16

Usbiological

Product number: 255281
Product name: Fananserin
Packaging: 10mg
Price: $403
Updated: 2021/12/16

TRC

Product number: F102368
Product name: Fananserin
Packaging: 2.5mg
Price: $165
Updated: 2021/12/16

ChemScene

Product number: CS-0024310
Product name: Fananserin
Purity: 99.83%
Packaging: 5mg
Price: $188
Updated: 2021/12/16

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Fananserin Chemical Properties,Usage,Production

Uses

Antipsychotic.

Uses

Fananserin is an antagonist of 5-HT2A.

Definition

ChEBI: LSM-2183 is a sulfonic acid derivative and a member of naphthalenes.

Biological Activity

5-HT 2A receptor antagonist that also displays high affinity at D 4 receptors (K i values are 0.26, 2.93, 25, 38, 70 and 726 nM for 5-HT 2A , D 4 , H 1 , α 1 , 5-HT 1A and D 2 receptors respectively). Inhibits inositol phosphate formation evoked by 5-HT in vitro (IC 50 = 7.76 nM) and antagonizes mescaline-induced head twitches in vivo .

in vivo

Fananserin displaces ^[125I]AMIK from 5-HT₂ receptors with an IC₅₀ of 0.21 nM in rat frontal cortex^[2].
Fananserin shows moderate affinity for alpha 1-adrenoceptors in the rat thalamus (IC₅₀ = 14 nM) and for histamine H1 receptors in the guinea-pig cerebellum (IC₅₀ = 13 nM)^[2].
Fananserin (0.5-4 mg/kg; p.o.) increases the duration of deep nonrapid eye movement (NREM) sleep at the expense of wakefulness in a dose-dependent manner^[3].

Animal Model:	Adult male Sprague Dawley rats (250-300 g)^[3]
Dosage:	0.5 mg/kg, 1 mg/kg,2 mg/kg, 4 mg/kg
Administration:	Oral administration
Result:	Increased the duration of deep nonrapid eye movement (NREM) sleep at the expense of wakefulness in a dose-dependent manner from 0.5 mg/kg.

IC 50

5-HT₂ Receptor: 0.37 nM (Ki); D₄ Receptor: 2.93 nM (Ki)

Fananserin Preparation Products And Raw materials

Raw materials

Preparation Products

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127625-29-0, FananserinRelated Search:

Afatinib (BIBW 2992) 1,8-NAPHTHOSULTAM Fananserin

2-[3-[4-(4-Fluorophenyl)piperazino]propyl]-2H-naphth[1,8-cd]isothiazole 1,1-dioxide

RP-62203

2-[3-[4-(4-Fluorophenyl)-1-piperazinyl]propyl]-2H-naphthyl[1,8-cd]isothiazole-1,1-dioxide

Fananserin

2H-Naphth[1,8-cd]isothiazole, 2-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-, 1,1-dioxide

2-(3-(4-(4-fluorophenyl)piperazin-1-yl)propyl)-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide

Fananserin,Inhibitor,5-HT Receptor,inhibit,5-HT2,RP62203,RP-62203,dopamine,Dopamine Receptor,Serotonin Receptor,5-hydroxytryptamine Receptor

Fananserin, 10 mM in DMSO

127625-29-0