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L-368,899hydrochloride

Product Name
L-368,899hydrochloride
CAS No.
148927-60-0
Chemical Name
L-368,899hydrochloride
Synonyms
L-368899 free base;L-368,899 hydrochlor;(2S)-2-amino-N-[(1R,3S,4S)-7,7-dimethyl-4-[[4-(2-methylphenyl)piperazin-1-yl]sulfonylmethyl]-3-bicyclo[2.2.1]heptanyl]-4-methylsulfonylbutanamide;(2S)-2-Amino-N-[(1S,2S,4R)-7,7-dimethyl-1-[[[4-(2-methylphenyl)-1-piperazinyl]sulfonyl]methyl]bicyclo[2.2.1]hept-2-yl]-4-(methylsulfonyl)butanamide;Butanamide, 2-amino-N-[(1S,2S,4R)-7,7-dimethyl-1-[[[4-(2-methylphenyl)-1-piperazinyl]sulfonyl]methyl]bicyclo[2.2.1]hept-2-yl]-4-(methylsulfonyl)-, (2S)-
CBNumber
CB71075242
Molecular Formula
C26H42N4O5S2
Formula Weight
554.77
MOL File
148927-60-0.mol
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L-368,899hydrochloride Property

storage temp. 
Store at +4°C
solubility 
Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
Off-White to Pale Yellow
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
MTB0000022
Product name
L-368,899 HYDROCHLORIDE
Purity
95.00%
Packaging
1MG
Price
$660.95
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
MTB0000022
Product name
L-368,899 HYDROCHLORIDE
Purity
95.00%
Packaging
10MG
Price
$823.46
Updated
2021/12/16
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L-368,899hydrochloride Chemical Properties,Usage,Production

Uses

L-368,899 Dihydrochloride is an oxytoxin antagonist and may be used in the treatment of early pregnancy failure.

Biological Activity

Potent, non-peptide and orally active oxytocin receptor antagonist (IC 50 = 8.9 nM) that displays > 40-fold selectivity over vasopressin V 1a and V 2 receptors (IC 50 values are 370 and 570 nM respectively). Antagonizes oxytocin-induced uterine contractions in vitro and in vivo .

in vivo

L-368,899 (0.1, 0.3, 1 mg/kg; infused i.v.; single) shows a dose-related antagonism of OT-stimulated uterine contractions with an AD50 value of 0.35 mg/kg in vivo[1].
L-368,899 (3, 10, 30 mg/kg; i.d.; single) inhibits the contractile effects of OT (AD50= 7 mg/kg) with a long (>4 h) duration of action in vivo (AD50: the dose of L-368,899 required to reduce the response to OT by 50%)[1].
L-368,899 (10 mg/kg, p.o.; single) shows bioavailability (AUC 0-6 h) of 35%[1].
L-368,899 (0.54, 1.8, 5.4 mg/kg; i.v.; single) reduces both oxytocin-induced and endogenous increases in plasma PGFM concentration[2].

Animal Model:Adult female Sprague-Dawley rats (250-350 g)[1].
Dosage:0.1, 0.3, 1 mg/kg
Administration:Infused intravenous injection; single.
Result:Inhibited OT-stimulated uterine contractions with an AD50 value of 0.35 mg/kg.
Animal Model:Adult female Sprague-Dawley rats (250-350 g)[1].
Dosage:3, 10, 30 mg/kg
Administration:Intraduodenal; single.
Result:Exhibited a antagonism of OT-stimulated uterine contractions with an AD50 of 7 mg/kg and duration of action more than 4 h.
Animal Model:Adult female Sprague-Dawley rats (250-350 g)[1].
Dosage:10 mg/kg
Administration:Oral administration, single.
Result:Showed orally active with bioavailability (AUC 0-6 h) of 35%.
Animal Model:Mature Dorset cross ewes (53-57 kg; Removal of ovaries)[2].
Dosage:0.54, 1.8, 5.4 mg/kg (3, 10 and 30 μg/kg/min for 3 h; dissolved in 0.9% saline).
Administration:Intravenous infusion; single.
Result:Led to a significant decrease in both the frequency (from 2.2 to 1.0 episodes/ewe) and amplitude (from 68.8 to 31.8 pg/mL) of episodes of increased plasma concentration of PGFM.

L-368,899hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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L-368,899hydrochloride Suppliers

China 10 Germany 1 United Kingdom 1 United States 4 Global 16
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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China
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EMMX Biotechnology LLC
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888-539-0666
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888-539-0666
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info@emmx.com
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United States
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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Shanghai Universal Biotech Co.,Ltd
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15921930842 15921930842
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yh-wang@univ-bio.com
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China
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Nantong QuanYi Biotechnology Co., Ltd
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0513-66337626 18051384581
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sales@chemhifuture.com
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China
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TargetMol Chemicals Inc.
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15002134094
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marketing@targetmol.cn
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China
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Suzhou Shentuo Pharmaceutical Technology Co., Ltd
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13911244683
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info@visonpharma.com
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China
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Biosynth Biological Technology (Suzhou) Co Ltd
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51288865780
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sales@biosynth.com
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China
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Santa Cruz Biotechnology Inc
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021-60936350
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scbt@scbt.com
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China
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Shanghai meikai technology co., ltd
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021-68689288 15300790979
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wechat 18721550091
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info@mkbio.com.cn
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China
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5000
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148927-60-0, L-368,899hydrochlorideRelated Search:

(R)-(+)-BORNYLAMINE 1,7,7-TRIMETHYLBICYCLO[2.2.1]HEPTAN-2-AMINE HYDROCHLORIDE (1R,2S)-(+)-BORNYLAMINE HCL L-368,899hydrochloride

  • (2S)-2-Amino-N-[(1S,2S,4R)-7,7-dimethyl-1-[[[4-(2-methylphenyl)-1-piperazinyl]sulfonyl]methyl]bicyclo[2.2.1]hept-2-yl]-4-(methylsulfonyl)butanamide
  • (2S)-2-amino-N-[(1R,3S,4S)-7,7-dimethyl-4-[[4-(2-methylphenyl)piperazin-1-yl]sulfonylmethyl]-3-bicyclo[2.2.1]heptanyl]-4-methylsulfonylbutanamide
  • Butanamide, 2-amino-N-[(1S,2S,4R)-7,7-dimethyl-1-[[[4-(2-methylphenyl)-1-piperazinyl]sulfonyl]methyl]bicyclo[2.2.1]hept-2-yl]-4-(methylsulfonyl)-, (2S)-
  • L-368,899 hydrochlor
  • L-368899 free base
  • 148927-60-0
  • C26H42N4O5S2HCl