2-Pyrimidinamine, 5-fluoro- (9CI)
Uses- Product Name
- 2-Pyrimidinamine, 5-fluoro- (9CI)
- CAS No.
- 1683-85-8
- Chemical Name
- 2-Pyrimidinamine, 5-fluoro- (9CI)
- Synonyms
- 5-fluoro- (9CI);2-amino-5-fluorouracil;5-Fluoro-2-pyrimidinamine;5-fluoropyriMidin-2-aMine;2-PyriMidinaMine,5-fluoro-;2-AMINO-5-FLUOROPYRIMIDINE;2-Pyrimidinamine, 5-fluoro- (9CI);2-Pyrimidinamine, 5-fluoro- (9CI) ISO 9001：2015 REACH;5-Fluoropyrimidin-2-amine, 2-Amino-5-fluoro-1,3-diazine
- CBNumber
- CB71081348
- Molecular Formula
- C4H4FN3
- Formula Weight
- 113.09
- MOL File
- 1683-85-8.mol
2-Pyrimidinamine, 5-fluoro- (9CI) Property
- Melting point:
- 192-193℃
- Boiling point:
- 280℃
- Density
- 1.372
- Flash point:
- 123℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- powder
- pka
- 2.13±0.10(Predicted)
- color
- Off white
- InChI
- InChI=1S/C4H4FN3/c5-3-1-7-4(6)8-2-3/h1-2H,(H2,6,7,8)
- InChIKey
- FUNBZJKZJGKXQB-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=C(F)C=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- A608700
- Product name
- 2-Amino-5-fluoropyrimidine
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 415277
- Product name
- 2-Amino-5-fluoropyrimidine
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- A608700
- Product name
- 2-Amino-5-fluoropyrimidine
- Packaging
- 2.5g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- PC400734
- Product name
- 2-Amino-5-fluoropyrimidine
- Packaging
- 5g
- Price
- $424
- Updated
- 2021/12/16
- Product number
- 073150
- Product name
- 2-Amino-5-fluoropyrimidine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $527
- Updated
- 2021/12/16
2-Pyrimidinamine, 5-fluoro- (9CI) Chemical Properties,Usage,Production
Uses
2-Amino-5-fluoropyrimidine can be used as a synthetic intermediate in pharmaceuticals and chemicals.
Synthesis
62802-42-0
1683-85-8
General Steps: Pre-step A Synthesis of 5-fluoro-2-pyrimidinamine A mixed solution of 2-chloro-5-fluoropyrimidine (280 μL, 2.264 mmol) and ammonia (5 mL, 68 mmol) in methanol (860 μL) was placed in a microwave reactor and heated to 110 °C for 30 min of reaction. After completion of the reaction, the reaction mixture was filtered and the resulting solid was washed with methanol. After drying, 5-fluoro-2-pyrimidinamine (247 mg, 2.184 mmol, 96% yield) was obtained as a white crystalline solid. Mass spectrum (electrospray positive ion mode) m/z 114.0 ([M+H]+). Mass spectrum (electrospray positive ionization mode) m/z 409.4 ([M+H]+) of 5-fluoro-2-pyrimidinamine (83 mg, 0.738 mmol). 1H NMR (400 MHz, methanol-d4) δ ppm 1.06-1.23 (m, 2H), 1.32-1.43 (m, 1H), 1.51-1.66 (m, 4H), 1.73-1.94 (m, 4H), 2.15-2.29 (m, 1H), 2.48-2.63 (m, 1H), 2.85-2.99 (m , 1H), 3.20-3.29 (m, 1H), 3.49 (dd, J = 14.02, 4.42 Hz, 1H), 3.69-3.84 (m, 1H), 3.94 (tt, J = 9.57, 4.83 Hz, 1H), 4.76 (dd, J = 6.82, 2.53 Hz, 1H), 7.85 (s, 0.7H), and 8.25 (s, 0.3H), 8.58 (s, 2H).
References
[1] Patent: US2013/345120, 2013, A1. Location in patent: Page/Page column
[2] Patent: US8901119, 2014, B2. Location in patent: Page/Page column
[3] Patent: US9617268, 2017, B2. Location in patent: Page/Page column 372
2-Pyrimidinamine, 5-fluoro- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Pyrimidinamine, 5-fluoro- (9CI) manufacturers
- Product
- 2-Pyrimidinamine, 5-fluoro- (9CI) 1683-85-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 2-Pyrimidinamine, 5-fluoro- (9CI) 1683-85-8
- Price
- US $36.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-29
- Product
- 2-Pyrimidinamine, 5-fluoro- (9CI) 1683-85-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2023-03-08