4-Pyrimidinamine, 5,6-dimethyl- (9CI)
- Product Name
- 4-Pyrimidinamine, 5,6-dimethyl- (9CI)
- CAS No.
- 54568-12-6
- Chemical Name
- 4-Pyrimidinamine, 5,6-dimethyl- (9CI)
- Synonyms
- 5,6-dimethyl-4-pyrimidinamine;5,6-Dimethylpyrimidin-4-amine;4-Pyrimidinamine, 5,6-dimethyl-;4-Pyrimidinamine, 5,6-dimethyl- (9CI);5,6-dimethyl-4-pyrimidinamine(SALTDATA: FREE)
- CBNumber
- CB71081863
- Molecular Formula
- C6H9N3
- Formula Weight
- 123.16
- MOL File
- 54568-12-6.mol
4-Pyrimidinamine, 5,6-dimethyl- (9CI) Property
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D502775
- Product name
- 5,6-dimethylpyrimidin-4-amine
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- D502775
- Product name
- 5,6-dimethylpyrimidin-4-amine
- Packaging
- 500mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 8924CC
- Product name
- 5,6-Dimethylpyrimidin-4-amine
- Packaging
- 250mg
- Price
- $127
- Updated
- 2021/12/16
- Product number
- CHM0139896
- Product name
- 5,6-DIMETHYL-4-PYRIMIDINAMINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $952.01
- Updated
- 2021/12/16
- Product number
- CHM0139896
- Product name
- 5,6-DIMETHYL-4-PYRIMIDINAMINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1976.78
- Updated
- 2021/12/16
4-Pyrimidinamine, 5,6-dimethyl- (9CI) Chemical Properties,Usage,Production
Synthesis
67434-65-5
54568-12-6
General procedure for the synthesis of 5,6-dimethylpyrimidin-4-amine from 4-chloro-5,6-dimethylpyrimidine: to a solution of 4-chloro-5,6-dimethylpyrimidine (0.18 g, 1.26 mmol) in anhydrous toluene (4 mL) was added sequentially sodium tert-butoxide (0.17 g, 1.77 mmol), Pd2(dba)3 (0.12 g, 0.13 mmol), BINAP (0.24 g, 0.38 mmol) and benzophenone imine (0.25 mL, 1.51 mmol). The reaction mixture was degassed (by three evacuation/nitrogen-filling cycles) and subsequently heated to 80 °C and stirred for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with ether (100 mL) and filtered through a pad of diatomaceous earth. The filtrate was concentrated under reduced pressure and the resulting oil was dissolved in tetrahydrofuran (20 mL) and 3 M aqueous hydrochloric acid (0.63 mL, 1.89 mmol) was added. The mixture was stirred at room temperature for 3 h. The mixture was subsequently concentrated under reduced pressure, neutralized with saturated aqueous sodium bicarbonate solution and diluted with dichloromethane (50 mL). The aqueous phase was back-extracted with dichloromethane (2 x 50 mL). The organic phases were combined, separated by phase separation tubing and concentrated. The residual orange solid was ground several times with ether and dried to afford the target product 5,6-dimethylpyrimidin-4-amine (0.067 g, 0.54 mmol, 42% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.38 (s, 1H), 4.78 (bs, 1H), 2.43 (s, 3H), 2.08 (s, 3H).
References
[1] Patent: WO2009/3997, 2009, A1. Location in patent: Page/Page column 21
[2] Chemische Berichte, 1901, vol. 34, p. 2813
4-Pyrimidinamine, 5,6-dimethyl- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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