4-Pyrimidinamine, 6-methyl- (9CI)
- Product Name
- 4-Pyrimidinamine, 6-methyl- (9CI)
- CAS No.
- 3435-28-7
- Chemical Name
- 4-Pyrimidinamine, 6-methyl- (9CI)
- Synonyms
- 6-Methyl-pyrimidi;-methylpyrimidin-4-amine;6-methylpyrimidin-4-amine;6-Methyl-4-pyriMidinaMine;4-Amino-6-methylpyrimidine;4-Pyrimidinamine,6-methyl-;4-methyl-6-aminopyrimidine;6-Methyl-4-aMine-pyriMidine;6-Methyl-pyrimidin-4-ylamine;Pyrimidine, 4-amino-6-methyl-
- CBNumber
- CB71081883
- Molecular Formula
- C5H7N3
- Formula Weight
- 109.13
- MOL File
- 3435-28-7.mol
4-Pyrimidinamine, 6-methyl- (9CI) Property
- Melting point:
- 197°C
- Boiling point:
- 194.6°C (rough estimate)
- Density
- 1.1118 (rough estimate)
- refractive index
- 1.5340 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 5.83±0.10(Predicted)
- form
- Solid
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C5H7N3/c1-4-2-5(6)8-3-7-4/h2-3H,1H3,(H2,6,7,8)
- InChIKey
- LAERIBHKDNBVOO-UHFFFAOYSA-N
- SMILES
- C1=NC(C)=CC(N)=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M340925
- Product name
- 6-Methylpyrimidin-4-amine
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- W5586
- Product name
- 6-Methylpyrimidin-4-amine
- Packaging
- 250mg
- Price
- $166
- Updated
- 2021/12/16
- Product number
- FA75018
- Product name
- 4-Amino-6-methylpyrimidine
- Packaging
- 250mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- W5586
- Product name
- 6-Methylpyrimidin-4-amine
- Packaging
- 1g
- Price
- $309
- Updated
- 2021/12/16
- Product number
- FA75018
- Product name
- 4-Amino-6-methylpyrimidine
- Packaging
- 500mg
- Price
- $320
- Updated
- 2021/12/16
4-Pyrimidinamine, 6-methyl- (9CI) Chemical Properties,Usage,Production
Synthesis
1118-61-2
149-73-5
3435-28-7
The general procedure for the synthesis of 4-amino-6-methylpyrimidine from 3-aminobut-2-enenenitrile and trimethyl orthoformate was as follows: in a 10 mL stainless steel pressure-resistant vessel, 1.0 g (11.7 mmol, 96% purity) of 3-aminobut-2-enenitrile, 2.48 g (23.4 mmol) of trimethyl orthoformate, and 1.42 g (17.5 mmol) of a 21 wt% ammonia-methanol solution. The mixture was stirred and reacted at 130°C for 15 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure. To the concentrate was added 10 mL of isopropanol and 660 mg of activated charcoal, stirred at 90 °C for 1 h and filtered. To the filtrate, 660 mg of activated carbon was added again and stirred at 90°C for 1 hour. After filtration, the filtrate was concentrated and 1.8 mL of isopropanol and 3 mL of toluene were added to the concentrate, and the mixture was heated to 90°C and then gradually cooled and stirred at -5°C for 1 hour. The precipitated solid was collected by filtration and dried under reduced pressure to give 326 mg (26% isolated yield, 99.5% purity, GC area percentage) of 6-methyl-4-aminopyrimidine as white crystals.The physical properties of 6-methyl-4-aminopyrimidine were as follows: 1H-NMR (DMSO-d6, δ/ppm): 2.17 (3H, s), 6.25 (1H, s) , 6.65 (2H, brs), 8.21 (1H, s); CI-MS (m/e): 110 (M+1).
References
[1] Patent: US2008/45712, 2008, A1. Location in patent: Page/Page column 4
4-Pyrimidinamine, 6-methyl- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Pyrimidinamine, 6-methyl- (9CI) manufacturers
- Product
- 4-Pyrimidinamine, 6-methyl- (9CI) 3435-28-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-06
- Product
- 4-Pyrimidinamine, 6-methyl- (9CI) 3435-28-7
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-16