4-Benzofurancarboxylic Acid

Product Name: 4-Benzofurancarboxylic Acid
CAS No.: 166599-84-4
Chemical Name: 4-Benzofurancarboxylic Acid
Synonyms: Degarelix Impurity 1;4-BENZOFURANCARBOXYLICACID;benzofuran-4-carboxylic acid;1-benzofuran-4-carboxylicaci;1-Benzofuran-4-carboxylic acid;1-benzofurane-4-carboxylic acid;4-Benzofurancarboxylic Acid ISO 9001：2015 REACH
CBNumber: CB71094180
Molecular Formula: C9H6O3
Formula Weight: 162.14
MOL File: 166599-84-4.mol

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4-Benzofurancarboxylic Acid Property

Boiling point:: 326℃
Density: 1.363
Flash point:: 151℃
storage temp.: Sealed in dry,Room Temperature
pka: 3.19±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C9H6O3/c10-9(11)7-2-1-3-8-6(7)4-5-12-8/h1-5H,(H,10,11)
InChIKey: WFAPIZKLEVLUMX-UHFFFAOYSA-N
SMILES: O1C2=CC=CC(C(O)=O)=C2C=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B203600
Product name: 4-BenzofurancarboxylicAcid
Packaging: 2.5g
Price: $1320
Updated: 2021/12/16

AK Scientific

Product number: 2267DA
Product name: Benzofuran-4-carboxylicacid
Packaging: 250mg
Price: $222
Updated: 2021/12/16

AK Scientific

Product number: 2267DA
Product name: Benzofuran-4-carboxylicacid
Packaging: 1g
Price: $546
Updated: 2021/12/16

Matrix Scientific

Product number: 123707
Product name: 4-Benzofurancarboxylicacid
Purity: 95+%
Packaging: 1g
Price: $1552
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0077917
Product name: BENZOFURAN-4-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 5G
Price: $2598.75
Updated: 2021/12/16

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4-Benzofurancarboxylic Acid Chemical Properties,Usage,Production

Uses

4-Benzofurancarboxylic Acid is a benzofuran derivative used in the preparation of dual orexin 1 and orexin 2 receptor antagonist which are useful for the treatment of sleep disorders.

Synthesis

41019-56-1

166599-84-4

General procedure for the synthesis of benzofuran-4-carboxylic acid from methyl benzofuran-4-carboxylate: a solution of LiOH (1.44 g, 34.3 mmol) in water (20 mL) was added to a mixture of THF (20 mL) and MeOH (20 mL) of methyl benzofuran-4-carboxylate (2.02 g, 11.4 mmol) and the reaction was stirred at room temperature for 16 The reaction was stirred for 16 hours at room temperature. After completion of the reaction, the solvent was removed by evaporation. The residue was dissolved in water (50 mL) and acidified with concentrated HCl to pH < 2. The precipitate was collected by filtration and dried to afford benzofuran-4-carboxylic acid (1.83 g, 99% yield). The product was characterized by 1H NMR (DMSO-d6): δ 13.10 (s, 1H), 8.14 (d, J = 2.1 Hz, 1H), 7.85-7.91 (m, 2H), 7.43 (t, J = 7.9 Hz, 1H), 7.33 (dd, J = 2.1, 1.0 Hz, 1H). Mass spectrum measured value: [M-H]? = 161.1.

References

[1] Patent: WO2017/155909, 2017, A1. Location in patent: Paragraph 0190
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 1797 - 1809
[3] Journal of Medicinal Chemistry, 1995, vol. 38, # 16, p. 3094 - 3105

4-Benzofurancarboxylic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Benzofurancarboxylic Acid Suppliers

Canada 2 China 91 India 2 United States 6 Global 101

Shanghai Naiys Biological Technology Co., Ltd

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Wuhan Chemduro Pharm Tech Co. Ltd.

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View Lastest Price from 4-Benzofurancarboxylic Acid manufacturers

R&D Scientific Inc.

Product: Benzofuran-4-carboxylic acid 166599-84-4
Price: US $890.00/g
Min. Order: 1g
Purity: 96
Supply Ability: 500 Kg
Release date: 2024-02-19

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Benzofurancarboxylic Acid 166599-84-4
Price: US $0.00-0.00/KG
Min. Order: 5g
Purity: 99%+
Supply Ability: 100 tons
Release date: 2019-12-25

Career Henan Chemical Co

Product: 4-Benzofurancarboxylic Acid 166599-84-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10000KGS
Release date: 2019-12-26

166599-84-4, 4-Benzofurancarboxylic AcidRelated Search:

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4-Benzofurancarboxylic Acid ISO 9001：2015 REACH

Degarelix Impurity 1

166599-84-4