4-METHYLBENZO(B)THIOPHENE-2-CARBOXYLICACID
- Product Name
- 4-METHYLBENZO(B)THIOPHENE-2-CARBOXYLICACID
- CAS No.
- 1735-13-3
- Chemical Name
- 4-METHYLBENZO(B)THIOPHENE-2-CARBOXYLICACID
- Synonyms
- OCANRQFAJMJHTR-UHFFFAOYSA-N;4-Methylbenzothiophene-2-carboxylic Acid;4-METHYLBENZO(B)THIOPHENE-2-CARBOXYLICACID;4-methyl-1-benzothiophene-2-carboxylic acid;Benzo[b]thiophene-2-carboxylic acid, 4-methyl-
- CBNumber
- CB71110086
- Molecular Formula
- C10H8O2S
- Formula Weight
- 192.23
- MOL File
- Mol file
4-METHYLBENZO(B)THIOPHENE-2-CARBOXYLICACID Property
- Melting point:
- 197-198 °C
- Boiling point:
- 386.1±22.0 °C(Predicted)
- Density
- 1.355±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 3.57±0.30(Predicted)
- Appearance
- Light brown to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 8952AA
- Product name
- 4-Methylbenzo[b]thiophene-2-carboxylicacid
- Packaging
- 100mg
- Price
- $215
- Updated
- 2021/12/16
- Product number
- 8952AA
- Product name
- 4-Methylbenzo[b]thiophene-2-carboxylicacid
- Packaging
- 250mg
- Price
- $308
- Updated
- 2021/12/16
- Product number
- CHM0376283
- Product name
- 4-METHYL-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.34
- Updated
- 2021/12/16
- Product number
- CM156521
- Product name
- 4-Methylbenzo[b]thiophene-2-carboxylicacid
- Purity
- 95%+
- Packaging
- 1g
- Price
- $848
- Updated
- 2021/12/16
- Product number
- A141188
- Product name
- 4-Methylbenzo[b]thiophene-2-carboxylicacid
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
4-METHYLBENZO(B)THIOPHENE-2-CARBOXYLICACID Chemical Properties,Usage,Production
Synthesis
146137-98-6
1735-13-3
The general procedure for the synthesis of 4-methylbenzo[b]thiophene-2-carboxylic acid using methyl 4-methylbenzo[b]thiophene-2-carboxylate as a raw material was as follows: a mixture of 203 mg of methyl 4-methylbenzo[b]thiophene-2-carboxylate, 50 mg of lithium hydroxide monohydrate, 2 mL of water, and 6 mL of methanol was stirred and reacted for 2 hours at 80 °C. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. An appropriate amount of water was added to the concentrated residue, followed by washing the residue with tert-butyl methyl ether three times. Concentrated hydrochloric acid was slowly added to the aqueous layer, acidified and extracted three times with tert-butyl methyl ether. The organic layers were combined, washed with saturated brine and dried over anhydrous magnesium sulfate. Finally, the dried organic layer was concentrated under reduced pressure to give 189 mg of 4-methylbenzo[b]thiophene-2-carboxylic acid (hereinafter referred to as "Compound 20"). The product was characterized by 1H-NMR (CDCl3) with chemical shifts δ: 8.25 (s, 1H), 7.73-7.71 (m, 1H), 7.40-7.38 (m, 1H), 7.22-7.20 (m, 1H), 2.66 (s, 3H).
References
[1] Patent: EP2926660, 2015, A1. Location in patent: Paragraph 0277; 0278
4-METHYLBENZO(B)THIOPHENE-2-CARBOXYLICACID Preparation Products And Raw materials
Raw materials
Preparation Products
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