4-Bromo-1-difluoromethoxy-2-methyl-benzene
- Product Name
- 4-Bromo-1-difluoromethoxy-2-methyl-benzene
- CAS No.
- 888327-32-0
- Chemical Name
- 4-Bromo-1-difluoromethoxy-2-methyl-benzene
- Synonyms
- 5-Bromo-2-(difluoromethoxy)toluene;4-BroMo-2-Methy-1-(difluoroMethoxy)benzene;4-Bromo-1-difluoromethoxy-2-methyl-benzene;1-Bromo-3-methyl-4-(difluoromethoxy)benzene;Benzene, 4-bromo-1-(difluoromethoxy)-2-methyl-
- CBNumber
- CB71113274
- Molecular Formula
- C8H7BrF2O
- Formula Weight
- 237.04
- MOL File
- 888327-32-0.mol
4-Bromo-1-difluoromethoxy-2-methyl-benzene Property
- Boiling point:
- 223℃
- Density
- 1.508
- Flash point:
- 108℃
- storage temp.
- Sealed in dry,Room Temperature
- form
- liquid
- color
- Colourless
Safety
- HS Code
- 2909309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B690183
- Product name
- 4-Bromo-1-(difluoromethoxy)-2-methylbenzene
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- V8736
- Product name
- 4-Bromo-1-(difluoromethoxy)-2-methylbenzene
- Packaging
- 5g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- V8736
- Product name
- 4-Bromo-1-(difluoromethoxy)-2-methylbenzene
- Packaging
- 10g
- Price
- $205
- Updated
- 2021/12/16
- Product number
- PC5868
- Product name
- 5-Bromo-2-(difluoromethoxy)toluene
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- V8736
- Product name
- 4-Bromo-1-(difluoromethoxy)-2-methylbenzene
- Packaging
- 1g
- Price
- $42
- Updated
- 2021/12/16
4-Bromo-1-difluoromethoxy-2-methyl-benzene Chemical Properties,Usage,Production
Synthesis
83190-02-7
888327-32-0
General procedure for the synthesis of 5-bromo-2-(difluoromethoxy)toluene from 4-(difluoromethoxy)-3-methylaniline: to a stirred solution of 4-amino-1-(difluoromethoxy)-2-methylbenzene (5 g, 28.90 mmol) in a mixture of hydrobromic acid (20 mL) and water (20 mL), at 0 °C, sodium nitrite (2.07 g 30.00 mmol) in aqueous solution (10 mL), and the titration process was controlled to be completed within 20 minutes. After the dropwise addition, the reaction mixture was continued to be stirred at 0 °C for 30 min. Subsequently, copper (I) bromide (4 g, 27.87 mmol) was added and the mixture was heated to 60 °C for 30 min of reaction. Upon completion of the reaction, the reaction mixture was extracted with ethyl acetate (3 x 50 mL), the organic layers were combined, washed once with water (10 mL), dried over anhydrous sodium sulfate and concentrated to give 2.5 g of 4-bromo-1-(difluoromethoxy)-2-methylbenzene in 37% yield.
References
[1] Patent: WO2006/55187, 2006, A1. Location in patent: Page/Page column 83
4-Bromo-1-difluoromethoxy-2-methyl-benzene Preparation Products And Raw materials
Raw materials
Preparation Products
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