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1-Bromo-4-chloro-2,5-difluorobenzene

Product Name
1-Bromo-4-chloro-2,5-difluorobenzene
CAS No.
172921-33-4
Chemical Name
1-Bromo-4-chloro-2,5-difluorobenzene
Synonyms
2,5-difluoro-4-chlorobromobenzene;4-chloro-2,5-difluorobromobenzene;5-Bromo-2-chloro-1,4-difluorobenzene;1-Bromo-4-chloro-2,5-difluorobenzene;Benzene, 1-bromo-4-chloro-2,5-difluoro-
CBNumber
CB71114549
Molecular Formula
C6H2BrClF2
Formula Weight
227.43
MOL File
Mol file
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1-Bromo-4-chloro-2,5-difluorobenzene Property

Boiling point:
189℃
Density 
1.805
Flash point:
68℃
storage temp. 
Sealed in dry,Room Temperature
Appearance
White to light yellow Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B685423
Product name
1-Bromo-4-chloro-2,5-difluorobenzene
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
B685423
Product name
1-Bromo-4-chloro-2,5-difluorobenzene
Packaging
500mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB64547
Product name
1-Bromo-4-chloro-2,5-difluorobenzene
Packaging
1g
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB64547
Product name
1-Bromo-4-chloro-2,5-difluorobenzene
Packaging
2g
Price
$136
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB64547
Product name
1-Bromo-4-chloro-2,5-difluorobenzene
Packaging
5G
Price
$270
Updated
2021/12/16
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1-Bromo-4-chloro-2,5-difluorobenzene Chemical Properties,Usage,Production

Synthesis

2613-30-1

172921-33-4

2. Preparation of 1-bromo-4-chloro-2,5-difluorobenzene: Anhydrous copper(II) bromide (2.7 g, 12.1 mmol) and tert-butyl nitrite (1.56 g, 15.1 mmol) were dissolved in anhydrous acetonitrile (25 mL) under anhydrous conditions. The reaction mixture was heated to 65°C, followed by the slow dropwise addition of 4-chloro-2,5-difluoroaniline (1.65 g, 10.1 mmol) solution in anhydrous acetonitrile (2 mL), during which vigorous gas escape was observed. Upon completion of the reaction, the mixture was cooled to room temperature, poured into 2N HCl and extracted twice with ether. The organic phases were combined, washed sequentially with 2N HCl and saturated sodium bicarbonate solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by rapid chromatography on silica gel (eluent: hexane) to afford the target compound 1-bromo-4-chloro-2,5-difluorobenzene as a white solid (1.11 g, 48.4% yield).1H NMR (CDCl3) δ: 7.38 (dd, 2H), 7.21 (dd, 2H).

References

[1] Patent: US2009/88322, 2009, A1. Location in patent: Page/Page column 8
[2] Patent: US2009/62125, 2009, A1. Location in patent: Page/Page column 8

1-Bromo-4-chloro-2,5-difluorobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Bromo-4-chloro-2,5-difluorobenzene Suppliers

China 69 India 2 United Kingdom 2 United States 8 Global 81
A.J Chemicals
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Email
sales@ajchem.in
Country
India
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