1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol

Product Name: 1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol
CAS No.: 101597-25-5
Chemical Name: 1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol
Synonyms: 1,1-Di(4-methoxyphenyl)prop-2-yn-1-ol;1,1-Dis(4-methoxphenyl)-2-propyn-1-ol;1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol;1,1-bis(4-METHOXYPHENYL)-2-PROPYN-1-OL;α-Ethynyl-4-methoxy-α-(4-methoxyphenyl)benzenemethanol;BenzeneMethanol, a-ethynyl-4-Methoxy-a-(4-Methoxyphenyl)-;Benzenemethanol, α-ethynyl-4-methoxy-α-(4-methoxyphenyl)-;alpha-Ethynyl-4-methoxy-alpha-(4-methoxy-phenyl)-benzenemethanol
CBNumber: CB71115874
Molecular Formula: C17H16O3
Formula Weight: 268.31
MOL File: 101597-25-5.mol

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1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol Property

Melting point:: 91.9-92.2℃
Boiling point:: 412.0±45.0 °C(Predicted)
Density: 1.156
storage temp.: 2-8°C
form: powder to crystal
pka: 11.72±0.29(Predicted)
color: White to Almost white
InChI: InChI=1S/C17H16O3/c1-4-17(18,13-5-9-15(19-2)10-6-13)14-7-11-16(20-3)12-8-14/h1,5-12,18H,2-3H3
InChIKey: RFNDMLXNYMQMGN-UHFFFAOYSA-N
SMILES: C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)(O)C#C

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Safety

HS Code: 2909.49.1500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5946
Product name: 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol
Packaging: 5G
Price: $111
Updated: 2025/07/31

TCI Chemical

Product number: B5946
Product name: 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol
Packaging: 25G
Price: $237
Updated: 2022/04/27

TRC

Product number: B591940
Product name: 1,1-bis(4-Methoxyphenyl)-2-propyn-1-ol
Packaging: 5g
Price: $375
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0973344
Product name: 1,1-BIS(4-METHOXYPHENYL)-2-PROPYN-1-OL
Purity: 95.00%
Packaging: 5MG
Price: $498.84
Updated: 2021/12/16

Activate Scientific

Product number: AS49605
Product name: 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol
Purity: 97%
Packaging: 1g
Price: $101
Updated: 2021/12/16

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1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol Chemical Properties,Usage,Production

Uses

1,1-bis(4-Methoxyphenyl)-2-propyn-1-ol (cas# 101597-25-5) is used in the synthetic preparation of photochromic pyranobenzopyran derivatives.

Preparation

The preparation of 1,1-bis(4-methoxyphenyl)-2-propyn-1-ol is as follows:18W % sodium acetylide in xylene/mineral oil 121.1mL (0.45mol, 1eq) was dissolved in anhydrous THF (1L) saturated with acetylene gas. After that 4,4-dimethoxybenzophenone 100g (0.41mol, 1eq) was put inside the reaction mixture under nitrogen and stirred for 24h at room temperature. The product was extracted by solvent extraction using ethyl acetate and water, organic layer was dried with MgSO4 and solid product on vacuum drier. After complete drying, the product again dissolve in ethyl acetate and poured into 1L hexane slowly under stirring which afford 8 as white color solid, yield (99g, 90%).

Synthesis

90-96-0

1066-54-2

101597-25-5

Trimethylsilylacetylene (4.5 g, 45 mmol) was dissolved in anhydrous tetrahydrofuran (150 mL) under nitrogen protection and cooled to -10°C. n-Butyllithium (1.6 M hexanes solution, 28.5 mL, 45 mmol) was slowly added, the temperature was maintained at -10°C, and the reaction mixture was stirred for 1 hour. Subsequently, a solution of anhydrous tetrahydrofuran (75 mL) of 4,4'-dimethoxybenzophenone (7.44 g, 40.8 mmol) was added dropwise at the same temperature. Stirring was continued at -10°C for 3 h. The reaction system was then slowly warmed to 0°C. A methanol (40.8 mL) solution of sodium hydroxide (2.16 g, 54 mmol) was added, followed by gradual warming of the reaction mixture to room temperature. The pH of the reaction solution was adjusted to 7 with acetic acid and the mixture was poured into water (546 mL). The aqueous phase was extracted with ethyl acetate (3 x 105 mL), the organic layers were combined and dried with anhydrous magnesium sulfate. After concentration under reduced pressure, the crude product was recrystallized by ethyl acetate/petroleum ether mixed solvent to give 7.5 g of 1,1-bis(4-methoxyphenyl)-2-propyn-1-ol (1c) as a light yellow solid in 88.4% yield.

References

[1] European Journal of Organic Chemistry, 2003, # 7, p. 1220 - 1230
[2] Angewandte Chemie - International Edition, 2014, vol. 53, # 17, p. 4341 - 4345
[3] Angew.Chem.Int.Ed., 2014, vol. 53, p. 4341 - 4345,5
[4] Tetrahedron, 2011, vol. 67, # 2, p. 401 - 407
[5] European Journal of Organic Chemistry, 2011, # 11, p. 2111 - 2119

1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol Preparation Products And Raw materials

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1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol Suppliers

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View Lastest Price from 1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol manufacturers

Qingdao RENAS Polymer Material Co., Ltd.

Product: 1,1-bis(4-methoxyphenyl)prop-2-yn-1-ol 101597-25-5
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2025-03-27

Henan Aochuang Chemical Co.,Ltd.

Product: 1,1-bis(4-METHOXYPHENYL)-2-PROPYN-1-OL 101597-25-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

Shaanxi Dideu New Materials Co. Ltd

Product: 1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol 101597-25-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-19

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101597-25-5