ChemicalBook > CAS DataBase List > 1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol

1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol

Product Name
1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol
CAS No.
101597-25-5
Chemical Name
1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol
Synonyms
1,1-Di(4-methoxyphenyl)prop-2-yn-1-ol;1,1-Dis(4-methoxphenyl)-2-propyn-1-ol;1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol;1,1-bis(4-METHOXYPHENYL)-2-PROPYN-1-OL;α-Ethynyl-4-methoxy-α-(4-methoxyphenyl)benzenemethanol;BenzeneMethanol, a-ethynyl-4-Methoxy-a-(4-Methoxyphenyl)-;Benzenemethanol, α-ethynyl-4-methoxy-α-(4-methoxyphenyl)-;alpha-Ethynyl-4-methoxy-alpha-(4-methoxy-phenyl)-benzenemethanol
CBNumber
CB71115874
Molecular Formula
C17H16O3
Formula Weight
268.31
MOL File
101597-25-5.mol
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1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol Property

Melting point:
91.9-92.2℃
Boiling point:
412.0±45.0 °C(Predicted)
Density 
1.156
storage temp. 
2-8°C
form 
powder to crystal
pka
11.72±0.29(Predicted)
color 
White to Almost white
InChI
InChI=1S/C17H16O3/c1-4-17(18,13-5-9-15(19-2)10-6-13)14-7-11-16(20-3)12-8-14/h1,5-12,18H,2-3H3
InChIKey
RFNDMLXNYMQMGN-UHFFFAOYSA-N
SMILES
C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)(O)C#C
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Safety

HS Code 
2909.49.1500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B5946
Product name
1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol
Packaging
5G
Price
$111
Updated
2025/07/31
TCI Chemical
Product number
B5946
Product name
1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol
Packaging
25G
Price
$237
Updated
2022/04/27
TRC
Product number
B591940
Product name
1,1-bis(4-Methoxyphenyl)-2-propyn-1-ol
Packaging
5g
Price
$375
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0973344
Product name
1,1-BIS(4-METHOXYPHENYL)-2-PROPYN-1-OL
Purity
95.00%
Packaging
5MG
Price
$498.84
Updated
2021/12/16
Activate Scientific
Product number
AS49605
Product name
1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol
Purity
97%
Packaging
1g
Price
$101
Updated
2021/12/16
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1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol Chemical Properties,Usage,Production

Uses

1,1-bis(4-Methoxyphenyl)-2-propyn-1-ol (cas# 101597-25-5) is used in the synthetic preparation of photochromic pyranobenzopyran derivatives.

Preparation

The preparation of 1,1-bis(4-methoxyphenyl)-2-propyn-1-ol is as follows:18W % sodium acetylide in xylene/mineral oil 121.1mL (0.45mol, 1eq) was dissolved in anhydrous THF (1L) saturated with acetylene gas. After that 4,4-dimethoxybenzophenone 100g (0.41mol, 1eq) was put inside the reaction mixture under nitrogen and stirred for 24h at room temperature. The product was extracted by solvent extraction using ethyl acetate and water, organic layer was dried with MgSO4 and solid product on vacuum drier. After complete drying, the product again dissolve in ethyl acetate and poured into 1L hexane slowly under stirring which afford 8 as white color solid, yield (99g, 90%).

Synthesis

90-96-0

1066-54-2

101597-25-5

Trimethylsilylacetylene (4.5 g, 45 mmol) was dissolved in anhydrous tetrahydrofuran (150 mL) under nitrogen protection and cooled to -10°C. n-Butyllithium (1.6 M hexanes solution, 28.5 mL, 45 mmol) was slowly added, the temperature was maintained at -10°C, and the reaction mixture was stirred for 1 hour. Subsequently, a solution of anhydrous tetrahydrofuran (75 mL) of 4,4'-dimethoxybenzophenone (7.44 g, 40.8 mmol) was added dropwise at the same temperature. Stirring was continued at -10°C for 3 h. The reaction system was then slowly warmed to 0°C. A methanol (40.8 mL) solution of sodium hydroxide (2.16 g, 54 mmol) was added, followed by gradual warming of the reaction mixture to room temperature. The pH of the reaction solution was adjusted to 7 with acetic acid and the mixture was poured into water (546 mL). The aqueous phase was extracted with ethyl acetate (3 x 105 mL), the organic layers were combined and dried with anhydrous magnesium sulfate. After concentration under reduced pressure, the crude product was recrystallized by ethyl acetate/petroleum ether mixed solvent to give 7.5 g of 1,1-bis(4-methoxyphenyl)-2-propyn-1-ol (1c) as a light yellow solid in 88.4% yield.

References

[1] European Journal of Organic Chemistry, 2003, # 7, p. 1220 - 1230
[2] Angewandte Chemie - International Edition, 2014, vol. 53, # 17, p. 4341 - 4345
[3] Angew.Chem.Int.Ed., 2014, vol. 53, p. 4341 - 4345,5
[4] Tetrahedron, 2011, vol. 67, # 2, p. 401 - 407
[5] European Journal of Organic Chemistry, 2011, # 11, p. 2111 - 2119

1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol Suppliers

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View Lastest Price from 1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol manufacturers

Qingdao RENAS Polymer Material Co., Ltd.
Product
1,1-bis(4-methoxyphenyl)prop-2-yn-1-ol 101597-25-5
Price
US $0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
20 tons
Release date
2025-03-27
Henan Aochuang Chemical Co.,Ltd.
Product
1,1-bis(4-METHOXYPHENYL)-2-PROPYN-1-OL 101597-25-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-29
Shaanxi Dideu New Materials Co. Ltd
Product
1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol 101597-25-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-02-19

101597-25-5, 1,1-Bis(4-methoxyphenyl)-2-propyn-1-olRelated Search:

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  • 1,1-Dis(4-methoxphenyl)-2-propyn-1-ol
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  • α-Ethynyl-4-methoxy-α-(4-methoxyphenyl)benzenemethanol
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