prifuroline
- Product Name
- prifuroline
- CAS No.
- 70833-07-7
- Chemical Name
- prifuroline
- Synonyms
- prifuroline;3-(benzofuran-2-yl)-N,N-dimethyl-3,4-dihydro-2H-pyrrol-5-amine;3-(Benzofuran-2-yl)-3,4-dihydro-N,N-dimethyl-2H-pyrrol-5-amine;2H-Pyrrol-5-amine, 3-(2-benzofuranyl)-3,4-dihydro-N,N-dimethyl-;3-(benzofuran-2-yl)-N,N-dimethyl-3,4-dihydro-2H-pyrrol-5-amine(WXC06062)
- CBNumber
- CB71116538
- Molecular Formula
- C14H16N2O
- Formula Weight
- 228.29
- MOL File
- 70833-07-7.mol
prifuroline Property
- Boiling point:
- 383.8±31.0 °C(Predicted)
- Density
- 1.18±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 8.55±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- API0016654
- Product name
- PRIFUROLINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.27
- Updated
- 2021/12/16
prifuroline Chemical Properties,Usage,Production
Uses
Prifuroline is an antiarrhythmic agent.
in vivo
Prifuroline is an antiarrhythmic agent. Prifuroline dose-dependently antagonizes the arrhythmogenic action of aconitine in rats, when administered either intravenously (5, 10 or 20 mg/kg) or intraduodenally (10, 20 or 50 mg/kg). Prifuroline also diminishes ventricular susceptibility to electrical stimulation in open-chest rats. The arrhythmias induced in dogs by coronary artery ligation are markedly antagonized by Prifuroline after doses of 5 and 10 mg/kg i.v. or 30 mg/kg intraduodenally. The duration of its antiarrhythmic activity in this model of arrhythmias in conscious dogs is much longer after intraduodenal than after i.v. administration[1].
References
[1] Benharkate M, et al. Antiarrhythmic and hemodynamic effects of prifuroline. Arzneimittelforschung. 1986 Dec;36(12):1761-7. PMID:3566836
prifuroline Preparation Products And Raw materials
Raw materials
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