Tropodifene
- Product Name
- Tropodifene
- CAS No.
- 15790-02-0
- Chemical Name
- Tropodifene
- Synonyms
- Tropaphen;Tropodifene;(8-Methyl-8-azabicyclo[3.2.1]octan-3-yl) 3-(4-acetyloxyphenyl)-2-phenylpropanoate;Benzenepropanoic acid, 4-(acetyloxy)-α-phenyl-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
- CBNumber
- CB71117388
- Molecular Formula
- C25H29NO4
- Formula Weight
- 407.507
- MOL File
- 15790-02-0.mol
Tropodifene Property
- Boiling point:
- 508.5±50.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 9.99±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- API0012751
- Product name
- TROPODIFENE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.68
- Updated
- 2021/12/16
Tropodifene Chemical Properties,Usage,Production
Uses
Tropodifene (Tropaphen) is an α-Adrenergic receptor inhibitor.
in vivo
Tropaphen has a beneficial effect on hypertension. The therapeutic effect of this preparation is more constant in diseases accompanied by spasm of the peripheral vessels. Tropaphen has a very marked adrenolytic and vasodilator action. It greatly lowers the tone of the peripheral vessels. The preparation is effective starting with a dose of 0.1 mg/kg. After injection of the drug in a dose of 0.25 mg/kg, a considerable and gradually progressive decrease in the perfusion pressure takes place. The pressure falls by 30-35% and remained at a low level for 90-100 min. With a dose of tropaphen of 0.5 mg/kg, the perfusion pressure falls by 40-45% and remains low for 120 min or more. Strong vasodilatation is also observed after injection of tropaphen into intact rabbits[1].
References
[1] Mashkovskii MD, et al. The action of tropaphen on the peripheral vessels. Pharmacology. 1964. 58. 69-71.
Tropodifene Preparation Products And Raw materials
Raw materials
Preparation Products
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