Imirestat

Product Name: Imirestat
CAS No.: 89391-50-4
Chemical Name: Imirestat
Synonyms: HOE-843;AL-1576;Imirestat;Alcon 1576;Imirestat, 10 mM in DMSO;2,7-Difluorospiro[fluorene-9,4’-imidazolidine]-2’,5’-dione;2,7-Difluorospiro[Fluorene-9,4'-IMidazolidine]-2',5'-Dione;2,7-Difluorospiro[9H-fluorene-9,4'-imidazolidine]-2',5'-dione;Spiro[9H-fluorene-9,4'-imidazolidine]-2',5'-dione, 2,7-difluoro-;2,7-Difluoro-2'H,5'H-spiro[fluorene-9,4'-imidazolidine]-2',5'-dione
CBNumber: CB71118103
Molecular Formula: C15H8F2N2O2
Formula Weight: 286.23
MOL File: 89391-50-4.mol

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Imirestat Property

Density: 1.58±0.1 g/cm3(Predicted)
pka: 8.17±0.20(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6702
Product name: Imirestat
Purity: 99.52%
Packaging: 1mg
Price: $360
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0011651
Product name: IMIRESTAT
Purity: 95.00%
Packaging: 5MG
Price: $505.54
Updated: 2021/12/16

ChemScene

Product number: CS-6702
Product name: Imirestat
Purity: 99.52%
Packaging: 5mg
Price: $720
Updated: 2021/12/16

ChemScene

Product number: CS-6702
Product name: Imirestat
Purity: 99.52%
Packaging: 10mg
Price: $1224
Updated: 2021/12/16

ChemScene

Product number: CS-6702
Product name: Imirestat
Purity: 99.52%
Packaging: 20mg
Price: $2160
Updated: 2021/12/16

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Imirestat Chemical Properties,Usage,Production

Uses

Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.

in vivo

Imirestat (1 mg/kg) improves nerve conduction velocity but is without effect upon the resistance to hypoxic conduction blockade or the deficit in insulin-stimulated oubain-sensitive ATPase activity^[1].

References

[1] Carrington AL, et al. Aldose reductase inhibition with imirestat-effects on impulse conduction and insulin-stimulation of Na+/K(+)-adenosine triphosphatase activity in sciatic nerves of streptozotocin-diabetic rats. Diabetologia. 1991 Jun;34(6):397-401. DOI:10.1007/BF00403177

Imirestat Preparation Products And Raw materials

Raw materials

Preparation Products

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Imirestat Suppliers

China 25 United Kingdom 1 United States 6 Global 32

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89391-50-4, ImirestatRelated Search:

4,4'-Difluorobiphenyl (4'-FLUORO[1,1'-BIPHENYL]-2-YL)METHANAMINE 9H-Fluorene-9-methanamine doxenitoin (R)-1-(3-Fluorophenyl)ethylamine 5-FLUORO-2-METHYLBENZYLAMINE (S)-1-(3-Fluorophenyl)ethanamine Imirestat 9H-FLUOREN-9-AMINE 5,5-Diphenylhydantoin H-PHG-NH2 HCL (R)-ALPHA-METHYL-PHENYLGLYCINAMIDE (9H-FLUOREN-9-YLMETHYL)-METHYL-AMINE (3-fluorophenyl)(phenyl)methylamine 2-FLUOROFLUORENE 9H-Fluorene-9-carboxylic acid amide (RS)-1-(3-FLUOROPHENYL)ETHYLAMINE 2-(5-FLUORO-2-METHYLPHENYL)ACETALDEHYDE

Imirestat

2,7-Difluorospiro[9H-fluorene-9,4'-imidazolidine]-2',5'-dione

AL-1576

HOE-843

2,7-Difluorospiro[Fluorene-9,4'-IMidazolidine]-2',5'-Dione

Alcon 1576

2,7-Difluoro-2'H,5'H-spiro[fluorene-9,4'-imidazolidine]-2',5'-dione

Spiro[9H-fluorene-9,4'-imidazolidine]-2',5'-dione, 2,7-difluoro-

AL1576,Imirestat,HOE-843,inhibit,AL-1576,HOE843,Aldose Reductase,Alcon-1576,Inhibitor,Alcon1576

2,7-Difluorospiro[fluorene-9,4’-imidazolidine]-2’,5’-dione

Imirestat, 10 mM in DMSO

89391-50-4

C15H8F2N2O2