Fosfluconazole
- Product Name
- Fosfluconazole
- CAS No.
- 194798-83-9
- Chemical Name
- Fosfluconazole
- Synonyms
- Prodif;CS-969;Fosfluconazol;Fosfluconazole(INN);Fosfluconazole, >=98%;Dihydrogen phosphate ester;Fungal,Inhibitor,Fosfluconazole,inhibit;2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propyl dihydrogen phosphate;PHARMA PRODUCT FLUCONAZOLE USP 2-(2,4-DIFLUOROPHENYL)-1,3-BIS(1,2,4-TRIAZOL-1-YL) PROPAN-2-OL;2-(2,4-Difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propan-2-yl dihydrogen phosphate (Efinaconazole?Impurity)
- CBNumber
- CB71120322
- Molecular Formula
- C13H13F2N6O4P
- Formula Weight
- 386.25
- MOL File
- 194798-83-9.mol
Fosfluconazole Property
- Melting point:
- 223-224°
- Boiling point:
- 701.5±70.0 °C(Predicted)
- Density
- 1.70±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 6.2 mg/mL (16.05 mM)
- pka
- 1.44±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- CS-6032
- Product name
- Fosfluconazole
- Purity
- 98.08%
- Packaging
- 10mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-6032
- Product name
- Fosfluconazole
- Purity
- 98.08%
- Packaging
- 25mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-6032
- Product name
- Fosfluconazole
- Purity
- 98.08%
- Packaging
- 50mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-6032
- Product name
- Fosfluconazole
- Purity
- 98.08%
- Packaging
- 100mg
- Price
- $288
- Updated
- 2021/12/16
- Product number
- API0002762
- Product name
- FOSFLUCONAZOLE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $2317.35
- Updated
- 2021/12/16
Fosfluconazole Chemical Properties,Usage,Production
Description
Fosfluconazole is a phosphate prodrug of fluconazole, and it was launched in Japan as an intravenous injection for the treatment of candidiasis and cryptococcosis infections. Fluconazole, a triazole antifungal agent, is a selective inhibitor of fungal cytochrome P450 sterol C-14 alpha-demethylation, and it is widely used for the treatment of patients with serious systemic fungal infections. Fluconazole is marketed in both oral and intravenous formulations, the latter being a dilute (2 mg/ mL) infusion in saline due to the relatively poor water solubility of the drug. In patients needing high doses (＞400 mg) of fluconazole, a drawback of the IV formulation is the requirement of a high-volume infusion, which is undesirable in critically ill patients in whom fluid overload must be avoided. Fosfluconazole is a prodrug with approximately 40-fold higher water solubility than fluconazole, thereby achieving a substantial reduction in infusion volume. It is prepared in three steps starting from fluconazole. In the first step, fluconazole is converted to its dibenzyl phosphite derivative by reaction with phosphorous trichloride and benzyl alcohol. Subsequent oxidation of the phosphite to the corresponding phosphate with hydrogen peroxide and cleavage of the benzyl protecting groups by hydrogenolysis affords fosfluconazole. In vitro, fosfluconazole is at least 25-fold less potent than fluconazole against single isolates of Candida species and Cryptococcus neoformans. In vivo, it is rapidly hydrolyzed to fluconazole by phosphatase enzymes and exhibits similar efficacy to fluconazole in experimental models of fungal disease. The hydrolysis potential of fosfluconazole was initially demonstrated in homogenates of kidney, lung and liver of rat, dog, and human. Subsequently, in clinical trials with healthy volunteers (n＝24), fosfluconazole was shown to hydrolyze rapidly and almost completely to provide a 97% mean bioavailability of fluconazole. Less than 1% of the administered dose of fosfluconazole was excreted unchanged in the urine, with the majority (85.6%) of the dose eliminated as fluconazole. The terminal half-life was about 2.3 hours, and the volume of distribution was 0.2 L/kg. The time to reach steady state drug levels with 500 mg daily dose was about 10 days, which could be shortened to 3 days by administering loading doses of 1000 mgs on days 1 and 2 followed by 500 mg daily. Further studies showed that hepatic or renal impairment did not significantly alter the pharmacokinetic profile of fosfluconazole. In phase III studies in patients with deep-seated mycosis due to Candida or Cryptococcus (n＝160), a 2-day loading dose regimen of fosfluconazole provided efficacy range of 73.8% (in Japanese patients) to 91.7% (patients of non-Japanese origin). The adverse events seen in these trials were similar to those previously known with fluconazole therapy and included rash (3.1%), abnormal liver function values (2.5%), asthma (1.9%), and lightheadedness (1.9%).
Originator
Pfizer (Japan)
Definition
ChEBI: Fosfluconazole is a member of triazoles, a triazole antifungal drug and a conazole antifungal drug. It has a role as a prodrug. It is functionally related to a fluconazole.
brand name
Prodif
Fosfluconazole Preparation Products And Raw materials
Raw materials
Preparation Products
Fosfluconazole Suppliers
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2923
- Advantage
- 55
- Tel
- 0712-0712-2580635 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8849
- Advantage
- 52
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
- Fax
- +86-27-87599188
- Country
- China
- ProdList
- 1494
- Advantage
- 55
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3750
- Advantage
- 55
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9798
- Advantage
- 50
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2989
- Advantage
- 60
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9767
- Advantage
- 58
- Tel
- 0551-65629887 18010855303
- Fax
- 0551-65629887
- sales@hfnhsw.com
- Country
- China
- ProdList
- 262
- Advantage
- 58
- Tel
- 86(21)68097365
- Fax
- 86(21)33321566
- sales@anpharma.net
- Country
- China
- ProdList
- 4901
- Advantage
- 55
- Tel
- 010-52980412
- Fax
- 010-52980412
- chemsales@pharmasea.com.cn
- Country
- China
- ProdList
- 49
- Advantage
- 58
- Tel
- 0512-0512-63009836 15365350169
- Fax
- 0512-63006936
- helen@struchem.com
- Country
- China
- ProdList
- 3989
- Advantage
- 60
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9254
- Advantage
- 55
- Tel
- 021-61556450 15800904410
- Fax
- 021-61556450
- Country
- China
- ProdList
- 2837
- Advantage
- 58
- Tel
- 027-51335350 15107175693
- Fax
- 027-51335350
- bosenyuan@foxmail.com
- Country
- China
- ProdList
- 192
- Advantage
- 55
- Tel
- +86-400-851-9921
- Fax
- +86-10-82826195
- sales@pharmacodia.com
- Country
- China
- ProdList
- 2317
- Advantage
- 55
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9934
- Advantage
- 55
- Tel
- 86-21-50817262
- Fax
- 86-21-57712035
- sales@lancrix.com
- Country
- China
- ProdList
- 1503
- Advantage
- 55
- Tel
- 025-57798860
- sales@njromanme.com
- Country
- China
- ProdList
- 4534
- Advantage
- 58
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29797
- Advantage
- 68
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131981
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12308
- Advantage
- 58
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
- Country
- China
- ProdList
- 4587
- Advantage
- 58
- Tel
- 027-027-83778875 15807197853
- Fax
- 027-83991220
- 15807197853@163.com
- Country
- China
- ProdList
- 3979
- Advantage
- 58
- Tel
- 13127280945
- 285424065@qq.com
- Country
- China
- ProdList
- 9980
- Advantage
- 55
- Tel
- 028-64971018 18108168130
- Fax
- 86 028-64971018
- Country
- China
- ProdList
- 1781
- Advantage
- 55
- Tel
- 027-50476178
- Fax
- QQ644526144
- 644526144@qq.com
- Country
- China
- ProdList
- 418
- Advantage
- 58
- Tel
- 027-51831887 15337167856
- Fax
- 027-51837635 QQ1165326703
- hubeixinyuanshun@163.com
- Country
- China
- ProdList
- 10305
- Advantage
- 58
- Tel
- 13382066392
- Country
- CHINA
- ProdList
- 4880
- Advantage
- 58
- Tel
- 17317130613
- Fax
- QQ3358272972
- 3358272972@qq.com
- Country
- China
- ProdList
- 3238
- Advantage
- 58
- Tel
- 027-50478167
- Fax
- QQ 252994272
- 252994272@qq.com
- Country
- China
- ProdList
- 277
- Advantage
- 58
- Tel
- +86-400-002-6226 13028896684
- sales@rrkchem.com
- Country
- China
- ProdList
- 55827
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9730
- Advantage
- 58
- Tel
- 0571-85361029
- Fax
- 0571-85361029
- synstar518@163.com
- Country
- China
- ProdList
- 1991
- Advantage
- 58
- Tel
- 17825480238
- Fax
- QQ 3008233717
- 3008233717@qq.com
- Country
- China
- ProdList
- 9844
- Advantage
- 12
- Tel
- 0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25363
- Advantage
- 58
- Tel
- 571-88938639 +8617705817739
- Fax
- +86-571-88938652，+86-571- 88492614
- info@dycnchem.com
- Country
- CHINA
- ProdList
- 52867
- Advantage
- 58
- Tel
- +8615056975894
- Fax
- 86-0551-62678551
- shawn@hirisunpharm.com
- Country
- CHINA
- ProdList
- 9923
- Advantage
- 58
- Tel
- 86-571-88216897,88216896 13588875226
- Fax
- 86-571-88216895
- sales@hzclap.com
- Country
- CHINA
- ProdList
- 6313
- Advantage
- 58
- Tel
- +86-13806087780
- sale@simagchem.com
- Country
- China
- ProdList
- 17367
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9414
- Advantage
- 58
- Tel
- 2710913286@.com
- 1513643261@qq.com
- Country
- China
- ProdList
- 14253
- Advantage
- 58
- Tel
- +86-023-61398051 +8613650506873
- sales@chemdad.com
- Country
- China
- ProdList
- 39916
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11289
- Advantage
- 58
- Tel
- 0755-61348847 17820674378
- Fax
- 0755-21016893
- 2682116078@qq.com
- Country
- China
- ProdList
- 7844
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- chenjw@absin.cn
- Country
- China
- ProdList
- 24734
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 0755-84826604
- 3001783715@qq.com
- Country
- CHINA
- ProdList
- 2898
- Advantage
- 58
- Tel
- 021-51111890 15317326293
- sales@molnova.com
- Country
- China
- ProdList
- 4196
- Advantage
- 58
- Tel
- 400-400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 55023
- Advantage
- 58
View Lastest Price from Fosfluconazole manufacturers
- Product
- Fosfluconazole 194798-83-9
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24