2-HYDROXY-5-METHOXYBENZONITRILE

Product Name: 2-HYDROXY-5-METHOXYBENZONITRILE
CAS No.: 39835-11-5
Chemical Name: 2-HYDROXY-5-METHOXYBENZONITRILE
Synonyms: 2-HYDROXY-4-METHOXYBENZONITRILE;AKOS 233-40;2-Hydroxy-4-methoxybenzonitril;Benzonitrile, 2-hydroxy-4-methoxy-
CBNumber: CB7115738
Molecular Formula: C8H7NO2
Formula Weight: 149.15
MOL File: 39835-11-5.mol

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2-HYDROXY-5-METHOXYBENZONITRILE Property

Melting point:: 151 °C
Boiling point:: 330.4±27.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 6.79±0.10(Predicted)
Appearance: Light yellow to yellow Solid

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Safety

Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39
RIDADR: 3439
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: H972668
Product name: 2-Hydroxy-4-methoxybenzonitrile
Packaging: 50mg
Price: $55
Updated: 2021/12/16

AK Scientific

Product number: J50807
Product name: 2-Hydroxy-4-methoxybenzonitrile
Packaging: 5g
Price: $150
Updated: 2021/12/16

AK Scientific

Product number: J50807
Product name: 2-Hydroxy-4-methoxybenzonitrile
Packaging: 10g
Price: $250
Updated: 2021/12/16

AK Scientific

Product number: W6013
Product name: 2-Hydroxy-4-methoxybenzonitrile
Packaging: 10g
Price: $334
Updated: 2021/12/16

Matrix Scientific

Product number: 073023
Product name: 2-Hydroxy-4-methoxybenzonitrile
Purity: 95+%
Packaging: 1g
Price: $347
Updated: 2021/12/16

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2-HYDROXY-5-METHOXYBENZONITRILE Chemical Properties,Usage,Production

Synthesis

673-22-3

39835-11-5

The general procedure for the synthesis of 2-hydroxy-4-methoxybenzonitrile from 2-hydroxy-4-methoxybenzaldehyde is as follows: 2-hydroxy-4-methoxybenzaldehyde (20 g, 128.8 mmol), sodium acetate (35.05 g, 257.6 mmol), and nitroethane (19 mL, 257.6 mmol) were dissolved in glacial acetic acid (100 mL) and the mixture was heated under mild reflux conditions for 12 hours. Upon completion of the reaction, the reaction mixture was slowly poured into about 1000 mL of ice water (1:1 ratio of ice to water). The product was extracted with ethyl acetate (3 x 200 mL). The organic phases were combined and washed with sodium bicarbonate solution until the pH of the aqueous layer was about 8. Subsequently, the organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated in vacuum to afford 2-hydroxy-4-methoxybenzonitrile as a yellow oil (16.5 g, 86% yield).

References

[1] Synthetic Communications, 2004, vol. 34, # 11, p. 2025 - 2029
[2] Patent: US2004/259867, 2004, A1. Location in patent: Page/Page column 7
[3] Patent: US6399657, 2002, B1
[4] Journal of Medicinal Chemistry, 2003, vol. 46, # 8, p. 1470 - 1477
[5] Synlett, 2000, # 8, p. 1169 - 1171

2-HYDROXY-5-METHOXYBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-HYDROXY-5-METHOXYBENZONITRILE Suppliers

China 76 Germany 4 India 1 United Kingdom 2 United States 10 Global 93

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View Lastest Price from 2-HYDROXY-5-METHOXYBENZONITRILE manufacturers

Career Henan Chemical Co

Product: 2-Hydroxy-4-methoxybenzonitrile 39835-11-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98%HPLC
Supply Ability: g/kg/ton
Release date: 2020-02-01

39835-11-5, 2-HYDROXY-5-METHOXYBENZONITRILERelated Search:

2,4-DIMETHOXY-6-METHYLBENZONITRILE AKOS 233-19 2-METHOXY-4-(TRIFLUOROMETHOXY)BENZONITRILE 2,4,6-Trimethoxybenzonitrile AKOS 233-36 2,4,5-TRIMETHOXYBENZONITRILE 2-HYDROXY-5-METHOXYBENZONITRILE 4-METHOXY-2-(TRIFLUOROMETHOXY)BENZONITRILE 2,3,4-TRIMETHOXYBENZONITRILE 2,4-Dimethoxybenzonitrile

AKOS 233-40

2-HYDROXY-4-METHOXYBENZONITRILE

2-Hydroxy-4-methoxybenzonitril

Benzonitrile, 2-hydroxy-4-methoxy-

39835-11-5