Broperamole
- Product Name
- Broperamole
- CAS No.
- 33144-79-5
- Chemical Name
- Broperamole
- Synonyms
- TR-2378;Broperamole;1-[3-[5-(3-Bromophenyl)-2H-tetrazol-2-yl]propionyl]piperidine;1-Propanone, 3-[5-(3-bromophenyl)-2H-tetrazol-2-yl]-1-(1-piperidinyl)-
- CBNumber
- CB71178161
- Molecular Formula
- C15H18BrN5O
- Formula Weight
- 364.24
- MOL File
- 33144-79-5.mol
N-Bromosuccinimide Price
- Product number
- API0010861
- Product name
- BROPERAMOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.73
- Updated
- 2021/12/16
Broperamole Chemical Properties,Usage,Production
Originator
Broperamole,Onbio Inc.
Uses
Anti-inflammatory.
Manufacturing Process
A mixture of 32 g (0.108 mole) of 3-[5'-(3"- bromophenyl)-2'Htetrazole] propionic acid and 80 g of thionyl chloride in 250 ml of dry chloroform was stirred under reflux for 16 hours. Evaporation of the solvent and excess reagent under reduced pressure gave a tan oil which was redissolved in 300 ml of dry tetrahydrofuran. To this was added 20 ml of redistilled piperidine in 100 ml of dry tetrahydrofuran. The mixture was stirred for 15 min at room temperature. The tetrahydrofuran was then removed under reduced pressure and the residue well triturated with one liter of 0.1 N hydrochloric acid. The resulting semi-solid was taken up in 700 ml of ether and extracted with 300 ml of 3% aqueous sodium bicarbonate solution. The ether solution was then dried over calcium chloride, filtered, and cooled in the refrigerator. This deposited 25 g (69 %) of tan needles of N-3-[5'-(3"- bromophenyl)-2'H-tetrazole]propionyl piperidine; melting point 69°C.
Therapeutic Function
Antiinflammatory
Broperamole Preparation Products And Raw materials
Raw materials
Preparation Products
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