Dinalin
- Product Name
- Dinalin
- CAS No.
- 58338-59-3
- Chemical Name
- Dinalin
- Synonyms
- Dinalin;GOE1734;dinaline;PD-104208;Dinaline, Antineoplastic agent;Benzamide, 4-amino-N-(2-aminophenyl)-
- CBNumber
- CB71178530
- Molecular Formula
- C13H13N3O
- Formula Weight
- 227.26
- MOL File
- 58338-59-3.mol
Dinalin Property
- Melting point:
- 180.5°C
- Boiling point:
- 368.98°C (rough estimate)
- Density
- 1.1267 (rough estimate)
- refractive index
- 1.5600 (estimate)
- storage temp.
- Store at Room Tem.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- INB0001967
- Product name
- 4-AMINO-N-(2-AMINOPHENYL)-BENZAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.2
- Updated
- 2021/12/16
- Product number
- AM-0721
- Product name
- 4-Amino-N-(2-aminophenyl)-benzamide
- Purity
- 97%
- Packaging
- 1g
- Price
- $275
- Updated
- 2021/12/16
Dinalin Chemical Properties,Usage,Production
Uses
Dinaline (GOE 1734; PD 104 208; NSC 328786) is a potent and orally activity anticancer agent. Dinaline shows cytotoxicity and antitumor activity. Dinaline has the potential for the research of colorectal cancer[1].
in vivo
Dinaline (5.9, 7.7, 10 mg/kg; p.o.; 5 days per week for 10 weeks) inhibits tumor growth in rats[1].
| Animal Model: | 140-160 g, male Sprague-Dawley rats[1] |
| Dosage: | 5.9, 7.7, 10 mg/kg |
| Administration: | P.o.; 5 days per week for 10 weeks |
| Result: | Showed significant tumor growth inhibition in a dose-dependent manner with the ratio of median tumor volume of (T/C%) values of 0.4, 16 and 10.6 at 10, 7.7 and 5.9 mg/kg respectively. |
References
[1] Seelig MH, et al. Efficacy of dinaline and its methyl and acetyl derivatives against colorectal cancer in vivo and in vitro. Eur J Cancer. 1996 Oct;32A(11):1968-76. DOI:10.1016/0959-8049(96)00217-1
Dinalin Preparation Products And Raw materials
Raw materials
Preparation Products
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