2-(METHYLTHIO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-4(3H)-ONE

Product Name: 2-(METHYLTHIO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-4(3H)-ONE
CAS No.: 54346-18-8
Chemical Name: 2-(METHYLTHIO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-4(3H)-ONE
Synonyms: pyrazolo[1,5-a][1,3,5]triazin-4(3H);2-(Methylthio)pyrazolo[1,5-a][1,3,5]triazin-4-ol;2-(Methylthio)pyrazolo[1,5-a]-1,3,5-triazin-4-one;(Methylthio)pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one;2-(METHYLTHIO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-4(3H)-ONE;2-methylsulfanyl-6H-pyrazolo[1,5-a][1,3,5]triazin-4-one;Pyrazolo[1,5-a]-1,3,5-triazin-4(3H)-one, 2-(methylthio)-;2-(methylsulfanyl)pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one;2-(methylsulfanyl)-1H,4H-pyrazolo[1,5-a][1,3,5]triazin-4-one;2-(Methylsulfanyl)-3H,4H-pyrazolo[1,5-a][1,3,5]triazin-4-one
CBNumber: CB71215873
Molecular Formula: C6H6N4OS
Formula Weight: 182.2
MOL File: 54346-18-8.mol

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2-(METHYLTHIO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-4(3H)-ONE Property

Density: 1.68
storage temp.: Inert atmosphere,Room Temperature
pka: 7.03±0.20(Predicted)
Appearance: white solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M726060
Product name: 2-(Methylthio)pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one
Packaging: 10mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-0036036
Product name: 2-(Methylthio)pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one
Packaging: 100mg
Price: $104
Updated: 2021/12/16

ChemScene

Product number: CS-0036036
Product name: 2-(Methylthio)pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one
Packaging: 250mg
Price: $173
Updated: 2021/12/16

AK Scientific

Product number: W6858
Product name: 2-(Methylthio)pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one
Packaging: 250mg
Price: $173
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H66-1-4B
Product name: 2-(Methylthio)pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one
Packaging: 250mg
Price: $225
Updated: 2021/12/16

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2-(METHYLTHIO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-4(3H)-ONE Chemical Properties,Usage,Production

Synthesis

34682-99-0

74-88-4

54346-18-8

General procedure for the synthesis of 2-(methylthio)pyrazolo[1,5-α][1,3,5]triazin-4(1H)-one from 2-thio-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one (7.99 g, 0.05 mol) and iodomethane (3 mL, 0.05 mol): firstly, 2-thio-2,3-dihydro pyrazolo[1,5-a][1,3,5]triazin-4(1H)-one was first suspended in a solvent mixture of ethanol (200 mL) and 2M aqueous sodium hydroxide (48 mL). Since the mixture was too viscous, it needed to be diluted by adding about 10 mL of water. The mixture was then cooled to 0°C and iodomethane was slowly added dropwise. During the dropwise addition, the mixture briefly dissolved and then began to form a white precipitate. The reaction system was gradually warmed to room temperature with continuous stirring for 3 hours, after which it was left overnight. Upon completion of the reaction, it was cooled again to 0 °C, 2N aqueous sulfuric acid solution (58 mL) was added and stirred for 1 hour. The precipitate was collected by filtration, washed sequentially with water (200 mL) and cyclohexane (50 mL), and finally dried in a vacuum oven to afford the target product 2-(methylthio)pyrazolo[1,5-α][1,3,5]triazin-4(3H)-one (6.85 g, 79% yield) as a white solid. The product was confirmed by NMR hydrogen spectroscopy (DMSO-d6): δH 12.94 (s, 1H), 7.96 (d, J=1.9Hz, 1H), 6.34 (d, J=1.9Hz, 1H), 2.53 (s, 3H).

References

[1] Patent: WO2015/193169, A1. Location in patent: Page/Page column 50; 51
[1] Patent: , 2015, . Location in patent: Page/Page column 50; 51
[3] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 20, p. 5955 - 5966
[4] Patent: US2007/78136, 2007, A1. Location in patent: Page/Page column 50
[5] Patent: WO2011/79231, 2011, A1. Location in patent: Page/Page column 105

2-(METHYLTHIO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-4(3H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(METHYLTHIO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-4(3H)-ONE Suppliers

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View Lastest Price from 2-(METHYLTHIO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-4(3H)-ONE manufacturers

Career Henan Chemical Co

Product: 2-(METHYLTHIO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-4(3H)-ONE 54346-18-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-14

54346-18-8, 2-(METHYLTHIO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-4(3H)-ONERelated Search:

2-(METHYLTHIO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-4(3H)-ONE

2-(Methylsulfanyl)-3H,4H-pyrazolo[1,5-a][1,3,5]triazin-4-one

2-(Methylthio)pyrazolo[1,5-a][1,3,5]triazin-4-ol

2-(Methylthio)pyrazolo[1,5-a]-1,3,5-triazin-4-one

2-(methylsulfanyl)-1H,4H-pyrazolo[1,5-a][1,3,5]triazin-4-one

(Methylthio)pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one

2-methylsulfanyl-6H-pyrazolo[1,5-a][1,3,5]triazin-4-one

pyrazolo[1,5-a][1,3,5]triazin-4(3H)

Pyrazolo[1,5-a]-1,3,5-triazin-4(3H)-one, 2-(methylthio)-

2-(methylsulfanyl)pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one

2-(methylthioyl)pyridineazolebenzo[1,5-α] [1,3,5]triazine-4(3H)-one

54346-18-8