4-BROMO-1-METHYL-1H-INDAZOLE
- Product Name
- 4-BROMO-1-METHYL-1H-INDAZOLE
- CAS No.
- 365427-30-1
- Chemical Name
- 4-BROMO-1-METHYL-1H-INDAZOLE
- Synonyms
- 4-Bromo-1-methylindazole;1-Methyl-4-bromoindazole;4-BROMO-1-METHYL-1H-INDAZOLE;1H-Indazole, 4-bromo-1-methyl-
- CBNumber
- CB71215949
- Molecular Formula
- C8H7BrN2
- Formula Weight
- 211.06
- MOL File
- 365427-30-1.mol
4-BROMO-1-METHYL-1H-INDAZOLE Property
- Boiling point:
- 293.6±13.0 °C(Predicted)
- Density
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 0.26±0.30(Predicted)
- form
- solid
- color
- Off-white
- InChI
- InChI=1S/C8H7BrN2/c1-11-8-4-2-3-7(9)6(8)5-10-11/h2-5H,1H3
- InChIKey
- AQUSISHVASVOBL-UHFFFAOYSA-N
- SMILES
- N1(C)C2=C(C(Br)=CC=C2)C=N1
N-Bromosuccinimide Price
- Product number
- B697245
- Product name
- 4-Bromo-1-methylindazole
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B697245
- Product name
- 4-Bromo-1-methylindazole
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CS-0045009
- Product name
- 4-Bromo-1-methyl-1H-indazole
- Purity
- 98.98%
- Packaging
- 1g
- Price
- $42
- Updated
- 2021/12/16
- Product number
- OR60015
- Product name
- 4-Bromo-1-methyl-1H-indazole
- Packaging
- 1g
- Price
- $56
- Updated
- 2021/12/16
- Product number
- 3H32-9-D2
- Product name
- 4-Bromo-1-methyl-1H-indazole
- Packaging
- 1g
- Price
- $61
- Updated
- 2021/12/16
4-BROMO-1-METHYL-1H-INDAZOLE Chemical Properties,Usage,Production
Synthesis
74-88-4
186407-74-9
365427-30-1
590417-93-9
GENERAL METHOD: 4-Bromo-1H-indazole (1 eq.) was mixed with potassium carbonate (3 eq.) in acetone (15-30 mL) and stirred at room temperature for 30 minutes. Subsequently, iodomethane (1.2-1.8 eq.) was slowly added to the reaction system and the reaction was heated under reflux conditions for 3-8 hours. After completion of the reaction, acetone was removed by evaporation under reduced pressure and the residue was dissolved in ethyl acetate (30 mL). The organic phase was washed with saturated saline (3 x 15 mL), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel fast column chromatography (eluent: ethyl acetate/cyclohexane, 1:2 or dichloromethane) to afford the target products 4-bromo-1-methyl-1H-indazole and 4-bromo-2-methyl-2H-indazole, respectively.
References
[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 17, p. 5296 - 5304
4-BROMO-1-METHYL-1H-INDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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