[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate

Product Name: [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate
CAS No.: 52435-06-0
Chemical Name: [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate
Synonyms: AY25;LRH-A;AY 25;AY-25;LHRH-A;LHRH-A2;TAP 127;Wy-18481;AY-25205;leuprolideIS
CBNumber: CB71216269
Molecular Formula: C56H78N16O12
Formula Weight: 1167.32
MOL File: 52435-06-0.mol

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[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate Property

Density: 1.48±0.1 g/cm3(Predicted)
pka: 9.82±0.15(Predicted)
form: Solid
color: White to off-white
Sequence: {Pyr}-His-Trp-Ser-Tyr-{d-Ala}-Leu-Arg-Pro-NHEt

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H360May damage fertility or the unborn child

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N-Bromosuccinimide Price

AvaChem

Product number: 2232
Product name: Alarelin
Packaging: 50mg
Price: $390
Updated: 2021/12/16

AvaChem

Product number: 2232
Product name: Alarelin
Packaging: 1g
Price: $740
Updated: 2021/12/16

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[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate Chemical Properties,Usage,Production

Chemical Properties

Off-white freeze-dried powder. Soluble in water and saline.

Uses

(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (Surfagon, Mwt 1167.34 Da) is an agonist of gonadotropin-releasing hormone (GnRH). (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH can be used as an internal standard for the LC-MS analysis of leuprorelide acetate. (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH has potential applications in biochemical analysis and fertility[1][2][3].

in vivo

(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (2 μg/kg; i.p.; single dose) significantly increases anxiety behavior in adult male rats with and without gonadectomy^[2].
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (50 μg; single dose) improves the fertility of cows after fertilization and prevents embryo death when combined with Ainil (30 μL/kg)^[3].

References

[1] Wan B, et al. Polymer source affects in vitro-in vivo correlation of leuprolide acetate PLGA microspheres. Int J Pharm. 2022 Sep 25;625:122032. DOI:10.1016/j.ijpharm.2022.122032
[2] Masalova OO, et al. Effect of Surfagon on Open Field and Elevated Plus Maze Behavior of Gonadectomized and Non-Gonadectomized Male Rats. Bull Exp Biol Med. 2019 Nov;168(1):52-54. DOI:10.1007/s10517-019-04644-4
[3] Kraevskiy A Y, et al. Surfagon and Ketaprofen for increasing fertility and preventing embryonic death in cows after insemination AY[J]. Ukrainian Journal of Ecology, 2020, 10(4): 159-164.

[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate Suppliers

China 6 United States 1 Global 7

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
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Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
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Hubei xin bonus chemical co. LTD

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TargetMol Chemicals Inc.

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Biosynth Biological Technology (Suzhou) Co Ltd

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Cohesion Biosciences

Tel: 0512-67583809
Email: sales@cohesionbio.com
Country: China
ProdList: 6282
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52435-06-0, [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrateRelated Search:

(Des-Gly10，D-Ala6，proethylamide9)-LRH

LHRH-A

LRH-A

luteinizing hormone releasing hormone (D-Ala^<6^>) analog

[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate

[D-Ala6]des-Gly10-GnRH ethylamide

[D-Ala6]des-Gly10-gonadotropin releasing hormone ethylamide

5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-D-Ala-L-Leu-L-Arg-L-Pro-NHEt

AY-25205

Wy-18481

(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

1-9-Luteinizing hormone-releasing factor (swine), 6-D-alanine-9-(N-ethyl-L-prolinamide)-

leuprolideIS

[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate USP/EP/BP

AY 25

AY25

AY-25

LHRH-A2

TAP 127

52435-06-0