1-CHLORO-4-IODO-2-NITROBENZENE
- Product Name
- 1-CHLORO-4-IODO-2-NITROBENZENE
- CAS No.
- 41252-95-3
- Chemical Name
- 1-CHLORO-4-IODO-2-NITROBENZENE
- Synonyms
- 2-Chloro-5-iodonitrobenzene;1-CHLORO-4-IODONITROBENZENE;4-Chloro-3-nitrophenyl iodide;1-CHLORO-4-IODO-2-NITROBENZENE;1-chloro-4-iodine-2-nitrobenzene;Benzene, 1-chloro-4-iodo-2-nitro-
- CBNumber
- CB7121889
- Molecular Formula
- C6H3ClINO2
- Formula Weight
- 283.45
- MOL File
- 41252-95-3.mol
1-CHLORO-4-IODO-2-NITROBENZENE Property
- Melting point:
- 74.5 °C
- Boiling point:
- 311.3±22.0 °C(Predicted)
- Density
- 2.094
- storage temp.
- 2-8°C(protect from light)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C382290
- Product name
- 1-Chloro-4-iodo-2-nitrobenzene
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C382290
- Product name
- 1-Chloro-4-iodo-2-nitrobenzene
- Packaging
- 500mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- X0179
- Product name
- 1-Chloro-4-iodo-2-nitrobenzene
- Packaging
- 1g
- Price
- $216
- Updated
- 2021/12/16
- Product number
- HCH0066145
- Product name
- 2-CHLORO-5-IODO-NITROBENZENE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $765.23
- Updated
- 2021/12/16
- Product number
- HCH0066145
- Product name
- 2-CHLORO-5-IODO-NITROBENZENE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1065.66
- Updated
- 2021/12/16
1-CHLORO-4-IODO-2-NITROBENZENE Chemical Properties,Usage,Production
Synthesis
88-73-3
41252-95-3
In a jacketed reactor, acetic acid (450 mL) and acetic anhydride (225 mL) were added sequentially at 10 °C. Under stirring conditions, sodium periodate (NaIO4, 97.2 g) and iodine (I2, 77.2 g) were added to the above mixture in batches. The reaction temperature was controlled to be lower than 30°C and concentrated sulfuric acid (H2SO4, 720 mL) was added slowly and dropwise. Subsequently, o-chloronitrobenzene (2-chloronitrobenzene, retention time Rt = 11.11 min) was added all at once and the reaction mixture was gradually warmed up to 64°C. The reaction mixture was stirred continuously for at least 2 hours until process monitoring indicated that the reaction was essentially complete. Upon completion of the reaction, the mixture was cooled to room temperature and slowly transferred to another jacketed reactor containing pre-cooled sodium sulfite solution (Na2SO3, 250 g dissolved in 2000 mL of water). The wet filter cake was collected by filtration and washed with cold water (450 mL × 2). Finally, the filter cake was purified by crystallization with n-heptane to afford 2-chloro-5-iodonitrobenzene (2-chloro-5-iodonitrobenzene) in 62% yield and 98% purity by HPLC (Rt = 15.75 min). The structure of the product was analyzed by 1H NMR (400 MHz, CDCl3) δ 7.26-6.29 (m, 1H), 7.81-7.84 (dd, J = 8.4, 2.0 Hz, 1H), 8.17-8.16 (d, J = 2.0 Hz, 1H); 13C NMR (100 MHz, CDCl3) δ 90.5, 127.0, 133.2, 134.1, 142.1, 148.3; MS (ESI): m/z 282.9 (M) Confirmed.
References
[1] Patent: US2014/66634, 2014, A1. Location in patent: Paragraph 0026; 0027
[2] Patent: WO2014/37307, 2014, A1. Location in patent: Page/Page column 10
[3] Journal of the American Chemical Society, 1953, vol. 75, p. 4265,4266
[4] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1973, p. 595 - 599
[5] Journal of Heterocyclic Chemistry, 2009, vol. 46, # 5, p. 936 - 948
1-CHLORO-4-IODO-2-NITROBENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-CHLORO-4-IODO-2-NITROBENZENE manufacturers
- Product
- 1-CHLORO-4-IODO-2-NITROBENZENE 41252-95-3
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 200kgs
- Release date
- 2020-01-09