2-Bromo-3-methoxybenzoic acid
- Product Name
- 2-Bromo-3-methoxybenzoic acid
- CAS No.
- 88377-29-1
- Chemical Name
- 2-Bromo-3-methoxybenzoic acid
- Synonyms
- 2-Bromo-3-methoxybenzoic acid;Benzoic acid, 2-bromo-3-methoxy-
- CBNumber
- CB71240998
- Molecular Formula
- C8H7BrO3
- Formula Weight
- 231.04
- MOL File
- 88377-29-1.mol
2-Bromo-3-methoxybenzoic acid Property
- Melting point:
- 153-155 °C
- Boiling point:
- 330.7±27.0 °C(Predicted)
- Density
- 1.625±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 2.73±0.10(Predicted)
- color
- Pale Beige
Safety
- HS Code
- 2916310090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B700505
- Product name
- 2-Bromo-3-methoxybenzoicAcid
- Packaging
- 100mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 119572
- Product name
- 2-Bromo-3-methoxybenzoic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $58
- Updated
- 2021/12/16
- Product number
- OR400074
- Product name
- 2-Bromo-3-methoxybenzoicacid
- Packaging
- 1g
- Price
- $69
- Updated
- 2021/12/16
- Product number
- 2621-9-12
- Product name
- 2-Bromo-3-methoxybenzoic acid
- Packaging
- 1g
- Price
- $96
- Updated
- 2021/12/16
- Product number
- OR400074
- Product name
- 2-Bromo-3-methoxybenzoicacid
- Packaging
- 5g
- Price
- $235
- Updated
- 2021/12/16
2-Bromo-3-methoxybenzoic acid Chemical Properties,Usage,Production
Synthesis
3177-80-8
88377-29-1
General procedure for the synthesis of 2-bromo-3-methoxybenzoic acid from 2-amino-3-methoxybenzoic acid: 2-amino-3-methoxybenzoic acid (4.00 g, 23.9 mmol) was dissolved in 10% aqueous hydrobromic acid (54 ml) at 0 °C. Subsequently, an aqueous solution of sodium nitrite (1.65 g, 23.9 mmol) (17 ml) was slowly added. A 48% hydrobromic acid solution (22 ml) of copper (I) bromide (3.78 g, 26.3 mmol) was added dropwise to the reaction system under stirring. The reaction mixture was gradually warmed up to 60°C and maintained at this temperature for 2 hours. After completion of the reaction, the mixture was cooled to 0°C and the resulting precipitate was collected by filtration. The precipitate was washed with cold water and purified by recrystallization in water to finally obtain pure 2-bromo-3-methoxybenzoic acid (4.07 g, 74% yield). The product was analyzed by mass spectrometry (EI) and the molecular ion peak (MH+) of C8H7BrO3 was 232.
References
[1] Tetrahedron, 2001, vol. 57, # 23, p. 4967 - 4975
[2] Angewandte Chemie - International Edition, 2010, vol. 49, # 40, p. 7257 - 7260
[3] Patent: WO2009/55077, 2009, A1. Location in patent: Page/Page column 388-389
[4] Journal of Medicinal Chemistry, 1984, vol. 27, # 3, p. 363 - 367
[5] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 14, p. 3018 - 3022
2-Bromo-3-methoxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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