4-Chlorobenzoylformic acid
Uses- Product Name
- 4-Chlorobenzoylformic acid
- CAS No.
- 7099-88-9
- Chemical Name
- 4-Chlorobenzoylformic acid
- Synonyms
- (4-chlorophenyl)(oxo)acetic acid;2-(4-chlorophenyl)-2-oxoacetic acid;Benzeneacetic acid, 4-chloro-α-oxo-;4-chloro-alpha-oxo-benzeneacetic acid
- CBNumber
- CB71242992
- Molecular Formula
- C8H5ClO3
- Formula Weight
- 184.58
- MOL File
- 7099-88-9.mol
4-Chlorobenzoylformic acid Property
- Melting point:
- 94.5-95 °C
- Boiling point:
- 129-132 °C(Press: 0.5 Torr)
- Density
- 1.447±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.03±0.54(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2918300090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B405308
- Product name
- 2-(4-Chlorophenyl)-2-oxoaceticAcid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- W8010
- Product name
- 2-(4-Chlorophenyl)-2-oxoaceticacid
- Packaging
- 100mg
- Price
- $111
- Updated
- 2021/12/16
- Product number
- FC139387
- Product name
- 2-(4-Chlorophenyl)-2-oxoacetic acid
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FC139387
- Product name
- 2-(4-Chlorophenyl)-2-oxoacetic acid
- Packaging
- 2g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- FC139387
- Product name
- 2-(4-Chlorophenyl)-2-oxoacetic acid
- Packaging
- 5G
- Price
- $750
- Updated
- 2021/12/16
4-Chlorobenzoylformic acid Chemical Properties,Usage,Production
Uses
(4-Chlorophenyl)glyoxylic acid is a pharmaceutical intermediate that can be prepared in two steps from chlorobenzene and ethyl 2-chloro-2-oxoacetate. It can be used to prepare a compound that can be used to treat conditions associated with KIT and PDGFR.
Synthesis
34966-48-8
7099-88-9
Step 2: Synthesis of 2-(4-chlorophenyl)-2-oxoacetic acid Ethyl 2-(4-chlorophenyl)-2-oxoacetate (4.0 g, 18.9 mmol) was reacted with lithium hydroxide (1.98 g, 47.1 mmol) in a solvent mixture of THF:MeOH:H2O (76 mL, v/v 10:6:3) with stirring for 3 h at 25 °C. The reaction was carried out at 25 °C for 2 h. The reaction was carried out at 25 °C for 3 h. The reaction was completed with the use of concentrated hydrochloric acid. Upon completion of the reaction, the mixture was neutralized to pH 2-3 with concentrated hydrochloric acid. the resulting white precipitate was collected by filtration, washed three times with water and dried under vacuum to afford (4-chlorophenyl)glyoxalic acid (3.0 g, 86% yield) as a white solid. Mass spectrometry (electrospray positive ion mode) analysis showed that the theoretical mass-to-charge ratio of C8H5ClO3 was 184,186; the measured value was 185,187 [M + H]+.
References
[1] Organic Letters, 2014, vol. 16, # 13, p. 3528 - 3531
[2] Patent: US2017/22206, 2017, A1. Location in patent: Paragraph 0176; 0177; 0178
[3] Journal of the American Chemical Society, 1995, vol. 117, # 14, p. 3999 - 4013
[4] Patent: EP1486483, 2004, A1. Location in patent: Page 32
[5] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013, vol. 52, # 6, p. 818 - 823
4-Chlorobenzoylformic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chlorobenzoylformic acid manufacturers
- Product
- (4-Chlorophenyl)(oxo)acetic acid 7099-88-9
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-30