Jacobine.

Product Name: Jacobine.
CAS No.: 6870-67-3
Chemical Name: Jacobine.
Synonyms: Jacobine.;NSC-89936;Jacobine-RM;(20S)-15α,20-Epoxy-15,20-dihydro-12-hydroxysenecionan-11,16-dione;(15R,20S)-15,20-Dihydro-15,20-epoxy-12-hydroxysenecionan-11,16-dione;Spiro[[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-3(2H),2'-oxirane]-2,7(4H)-dione, 5,6,9,11,13,14,14a,14b-octahydro-6-hydroxy-3',5,6-trimethyl-, (2'S,3'S,5R,6R,14aR,14bR)-
CBNumber: CB71248363
Molecular Formula: C18H25NO6
Formula Weight: 351.39
MOL File: 6870-67-3.mol

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Jacobine. Property

Melting point:: 228°C
Boiling point:: 485.2°C (rough estimate)
Density: 1.2737 (rough estimate)
refractive index: 1.5100 (estimate)
pka: 12.89±0.60(Predicted)
IARC: 3 (Vol. 10, Sup 7) 1987

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Safety

RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 6870-67-3(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: J210395
Product name: Jacobine
Packaging: 0.25mg
Price: $160
Updated: 2021/12/16

TRC

Product number: J210395
Product name: Jacobine
Packaging: 0.5mg
Price: $305
Updated: 2021/12/16

TRC

Product number: J210395
Product name: Jacobine
Packaging: 1mg
Price: $570
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BJ161539
Product name: Jacobine
Packaging: 10mg
Price: $900
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BJ161539
Product name: Jacobine
Packaging: 25mg
Price: $1875
Updated: 2021/12/16

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Jacobine. Chemical Properties,Usage,Production

Description

This alkaloid of the pyrrolizidine group of bases occurs in Senecio cineraria D.C., S. crucifolia and S. Jacobea. It is a laevorotatory base with [α]¹⁷_D - 46.3° (CHCl 3 ). The alkaloid forms crystalline salts and derivatives, e.g. the hydrochloride, m.p. 220°C; [α]¹⁹_D - 14.3° (H20); nitrate, m.p. 234°C; methiodide, m.p. 255°C and the picrate, m.p. 180°C which is soluble in H20. The alkaloid contains two active hydrogens and on alkaline hydrolysis yields retronecine and jaconecic acid, ClOH16 0 6, m.p. 182°C; [α]²⁵_D + 31.7° containing three O-methyl groups

Uses

Jacobine is a pyrrolizidine alkaloid which has been shown to be an herbivore insect deterrent and may be used in the protection of vegetation. Extracted from Crassocephalum plant of West Africa.

Definition

ChEBI: Jacobine is a pyrrolizine alkaloid.

References

Manske., Can. J. Res., 5,651 (1931)
Hosking, Brandt., New Zealand J. Sci. Tech., 14,638 (1936)
Blackie.,Pharrn. J., 138,102 (1937)
Barger, Blackie., J. Chern. Soc., 584 (1937)
Bradbury, Willis., Austral. J. Chern., 9,258 (1956)
Geissman., ibid, 12,247 (1959)
Bradbury, Masamune., J. Arner. Chern. Soc., 81,5201 (1959)
Masamune., ibid, 82, 5253 (1960)
Freidrichsons, Mathieson, Sutor., Tetrahedron Lett., 35 (1960)

Jacobine. Preparation Products And Raw materials

Raw materials

Preparation Products

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Jacobine. Suppliers

China 20 France 1 India 2 United Kingdom 1 United States 4 Global 28

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6870-67-3, Jacobine.Related Search:

Jacobine.

(15R,20S)-15,20-Dihydro-15,20-epoxy-12-hydroxysenecionan-11,16-dione

(20S)-15α,20-Epoxy-15,20-dihydro-12-hydroxysenecionan-11,16-dione

NSC-89936

Spiro[[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-3(2H),2'-oxirane]-2,7(4H)-dione, 5,6,9,11,13,14,14a,14b-octahydro-6-hydroxy-3',5,6-trimethyl-, (2'S,3'S,5R,6R,14aR,14bR)-

Jacobine-RM

6870-67-3

C8H25NO6