6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one

Product Name: 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one
CAS No.: 192185-68-5
Chemical Name: 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one
Synonyms: 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one;2(1H)-Quinolinone, 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-
CBNumber: CB71258553
Molecular Formula: C27H22Cl2N4O
Formula Weight: 489.4
MOL File: 192185-68-5.mol

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6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one Property

Melting point:: 214 °C(Solv: acetonitrile (75-05-8); dichloromethane (75-09-2); methanol (67-56-1))
Boiling point:: 681.7±55.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
pka: 7.20±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one Chemical Properties,Usage,Production

Description

R 115777 is a farnesyl transferase inhibitor.

Uses

(Rac)-Tipifarnib ((Rac)-IND 58359; (Rac)-R115777) is a potent farnesyl protein transferase inhibitor that specifically targets the pro-tailation process of Ras proteins. (Rac)-Tipifarnib showed significant in vivo antitumor effects after oral administration to mice[1].

References

[1] Venet M, et al. Farnesyl protein transferase inhibitor ZARNESTRA? R115777-History of a discovery[J]. Current Topics in Medicinal Chemistry, 2003, 3(10): 1095-1102.

6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one Suppliers

China 1 United States 2 Global 3

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29357
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192185-68-5, 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-oneRelated Search:

4-(1H-IMIDAZOL-4-YLMETHYL)-PHENYLAMINE 4-(3-METHYL-BENZYL)-1H-IMIDAZOLE HCL 1-METHYL-4-PHENYL-1H-QUINOLIN-2-ONE 4-(1H-IMIDAZOL-4-YLMETHYL)-PHENYLAMINE 2HCL 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one

6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one

2(1H)-Quinolinone, 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-

192185-68-5

C27H22Cl2N4O