8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine

Product Name: 8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine
CAS No.: 279215-43-9
Chemical Name: 8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine
Synonyms: NN414;tifenazoxide;NN414 >=98% (HPLC);NN 414 - Tifenazoxide;6-Chloro-3-[[1-methylcyclopropyl]amino]-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide;2H-Thieno[3,2-e]-1,2,4-thiadiazin-3-amine, 6-chloro-N-(1-methylcyclopropyl)-, 1,1-dioxide;8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine
CBNumber: CB71261289
Molecular Formula: C9H10ClN3O2S2
Formula Weight: 291.78
MOL File: 279215-43-9.mol

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8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine Property

Melting point:: 251-252 °C (decomp)(Solv: methanol (67-56-1); water (7732-18-5))
Boiling point:: 448.0±55.0 °C(Predicted)
Density: 1.88±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble15mg/mL, clear
pka: -6.81±0.20(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0553
Product name: NN414
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $156
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0553
Product name: NN414
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $620
Updated: 2024/03/01

ChemScene

Product number: CS-0067041
Product name: Tifenazoxide
Purity: >99.0%
Packaging: 10mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0067041
Product name: Tifenazoxide
Purity: >99.0%
Packaging: 5mg
Price: $400
Updated: 2021/12/16

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8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine Chemical Properties,Usage,Production

Biological Activity

NN414 is a potent Kir6.2/SUR1 selective K-ATP channel opener. Activation of the pancreatic Kir6.2/SUR KATP channels inhibits insulin release to induce beta cell rest, reducing the workload of the beta cell which is thought may prove beneficial for patients with type 2 diabetes. A recent study found th at NN414 also triggered burst-like discharges in substantia nigra dopamine neurons. These K-ATP channel enabled burst-like discharges are associated with novelty-dependent exploratory behavior and may also have relevance to Parkinsonμs disease.

8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine Suppliers

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279215-43-9, 8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amineRelated Search:

8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine

tifenazoxide

6-Chloro-3-[[1-methylcyclopropyl]amino]-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide

NN414

2H-Thieno[3,2-e]-1,2,4-thiadiazin-3-amine, 6-chloro-N-(1-methylcyclopropyl)-, 1,1-dioxide

NN414 >=98% (HPLC)

NN 414 - Tifenazoxide

279215-43-9

C9H10ClN3O2S2