2-CARBOXY-3-ETHYL NITROBENZOATE
- Product Name
- 2-CARBOXY-3-ETHYL NITROBENZOATE
- CAS No.
- 16533-45-2
- Chemical Name
- 2-CARBOXY-3-ETHYL NITROBENZOATE
- Synonyms
- Ethyl 3-nitrophthalate;Azilsartan Impurity 81;Candesartan Impurity 14;1-Ethyl-3-nitrophthalate;2-CARBOXY-3-ETHYL NITROBENZOATE;2-carboxy-3-nitrobenzoate ethyl ester;2-(ethoxycarbonyl)-3-nitrobenzoic acid;2-(Ethoxycarbonyl)-6-nitrobenzoic acid;2-Carboxy-3-nitrobenzoic acid ethyl ester;2-(Ethoxycarbonyl)-6-nitrobenzoic Acid 2-
- CBNumber
- CB71263773
- Molecular Formula
- C10H9NO6
- Formula Weight
- 239.18
- MOL File
- 16533-45-2.mol
2-CARBOXY-3-ETHYL NITROBENZOATE Property
- Melting point:
- 157℃
- Boiling point:
- 415.5±35.0 °C(Predicted)
- Density
- 1.421±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 1.90±0.30(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C10H9NO6/c1-2-17-10(14)6-4-3-5-7(11(15)16)8(6)9(12)13/h3-5H,2H2,1H3,(H,12,13)
- InChIKey
- SZAOZGFHEAVFMM-UHFFFAOYSA-N
- SMILES
- C1(C(OCC)=O)=CC=CC([N+]([O-])=O)=C1C(O)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 126101
- Product name
- 2-(Ethoxycarbonyl)-6-nitrobenzoicacid
- Purity
- >95%
- Packaging
- 1g
- Price
- $270
- Updated
- 2021/12/16
- Product number
- Z4260
- Product name
- 2-(Ethoxycarbonyl)-6-nitrobenzoicacid
- Packaging
- 1g
- Price
- $414
- Updated
- 2021/12/16
- Product number
- CHM0993186
- Product name
- 2-(ETHOXYCARBONYL)-6-NITROBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.29
- Updated
- 2021/12/16
- Product number
- 126101
- Product name
- 2-(Ethoxycarbonyl)-6-nitrobenzoicacid
- Purity
- >95%
- Packaging
- 5g
- Price
- $810
- Updated
- 2021/12/16
- Product number
- 16533452
- Product name
- 2-(Ethoxycarbonyl)-6-nitrobenzoicacid
- Packaging
- 100g
- Price
- $559.98
- Updated
- 2021/12/16
2-CARBOXY-3-ETHYL NITROBENZOATE Chemical Properties,Usage,Production
Chemical Properties
White to off-white crystalline powder
Synthesis
603-11-2
16533-45-2
The general procedure for the synthesis of ethyl 2-carboxy-3-nitrobenzoate from 3-nitrophthalic acid is as follows: 3-nitrophthalic acid (35 g) was dissolved in ethanol (300 ml) containing concentrated hydrochloric acid. Sulfuric acid (20 ml) was slowly added to this solution and the reaction was then heated under reflux conditions for 24 hours. After completion of the reaction, the solvent was removed by distillation. The residue was poured into ice water (700 ml) and extracted with ethyl acetate. The organic layer was washed with water and back-extracted with aqueous potassium carbonate. The aqueous layer was acidified to acidity with hydrochloric acid and extracted with dichloromethane. The organic layer was washed with water and dried. Finally, the solvent was removed by distillation to afford the solid product ethyl 2-carboxy-3-nitrobenzoate (29 g, 74% yield), which could be used in subsequent reactions without further purification. The structure of the product was confirmed by 1H-NMR (90 MHz, CDCl3) and IR (Nujol): 1H-NMR δ: 1.43 (3H, t), 4.47 (2H, q), 7.70 (1H, t), 8.40 (2H, d), 9.87 (1H, br s); IR (Nujol) cm-1: 1725,1535, 1350,1300,1270.
References
[1] Patent: US5128356, 1992, A
[2] Patent: US5196444, 1993, A
2-CARBOXY-3-ETHYL NITROBENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CARBOXY-3-ETHYL NITROBENZOATE manufacturers
- Product
- 2-CARBOXY-3-ETHYL NITROBENZOATE 16533-45-2
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2025-04-11
- Product
- 2-Carboxy-3-ethyl nitrobenzoate 16533-45-2
- Price
- US $30.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000t/year
- Release date
- 2023-09-07
- Product
- 2-(Ethoxycarbonyl)-6-nitrobenzoic acid 16533-45-2
- Price
- US $10.00-100.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-03-06