2-Chloro-4-Trifluoromethylbenzaldehyde
Application- Product Name
- 2-Chloro-4-Trifluoromethylbenzaldehyde
- CAS No.
- 82096-91-1
- Chemical Name
- 2-Chloro-4-Trifluoromethylbenzaldehyde
- Synonyms
- 2-Chloro-4-(trifluoromethyl);2-Chloro-4-Trifluoromethylbenzaldehyde;Benzaldehyde, 2-chloro-4-(trifluoromethyl)-;2-Chloro-4-(trifluoromethyl)benzaldehyde,97%;2-Chloro-4-Trifluoromethylbenzaldehyde ISO 9001：2015 REACH
- CBNumber
- CB71270861
- Molecular Formula
- C8H4ClF3O
- Formula Weight
- 208.57
- MOL File
- 82096-91-1.mol
2-Chloro-4-Trifluoromethylbenzaldehyde Property
- Boiling point:
- 211.1±40.0 °C(Predicted)
- Density
- 1.423±0.06 g/cm3(Predicted)
- refractive index
- 1.4860
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- liquid
- color
- Clear, faint yellow
- Sensitive
- Air Sensitive
Safety
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B419375
- Product name
- 2-Chloro-4-(trifluoromethyl)benzaldehyde
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- Z0864
- Product name
- 2-Chloro-4-(trifluoromethyl)-benzaldehyde
- Packaging
- 1g
- Price
- $81
- Updated
- 2021/12/16
- Product number
- 2815-7-05
- Product name
- 2-Chloro-4-(trifluoromethyl)benzaldehyde
- Packaging
- 1g
- Price
- $149
- Updated
- 2021/12/16
- Product number
- J96500
- Product name
- 2-Chloro-4-(trifluoromethyl)-benzaldehyde
- Packaging
- 5g
- Price
- $170
- Updated
- 2021/12/16
- Product number
- Z0864
- Product name
- 2-Chloro-4-(trifluoromethyl)-benzaldehyde
- Packaging
- 5g
- Price
- $227
- Updated
- 2021/12/16
2-Chloro-4-Trifluoromethylbenzaldehyde Chemical Properties,Usage,Production
Application
2-Chloro-4-(trifluoromethyl)benzaldehyde can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical production processes.
Synthesis
1813-33-8
82096-91-1
The general procedure for the synthesis of 2-chloro-4-(trifluoromethyl)benzaldehyde from 2-chloro-4-(trifluoromethyl)benzonitrile was as follows: first, 2-chloro-4-(trifluoromethyl)benzenecarbonitrile (500 mg, 2.43 mmol) was dissolved in toluene (3 mL), and cooled to -78 °C under nitrogen protection. Subsequently, diisobutylaluminum hydride (DIBAL-H, 4865 μL, 4.86 mmol) was slowly added dropwise and the reaction was stirred for 1 hour at this temperature. Upon completion of the reaction, the mixture was slowly warmed to 0 °C and the reaction was quenched by the addition of acetic acid (2 mL) followed by the addition of water (10 mL). After continued stirring for 2 hours, the reaction mixture was extracted twice with ethyl acetate. The organic phases were combined, washed with Rochelle's salt solution, dried over anhydrous magnesium sulfate, filtered and concentrated. Finally, purification by Biotage 25 column chromatography using gradient elution (100% hexane to 20% dichloromethane/hexane) afforded 2-chloro-4-(trifluoromethyl)benzaldehyde (400 mg, 1.92 mmol, 78.8% yield) as a clear oil.
References
[1] Patent: WO2009/158426, 2009, A1. Location in patent: Page/Page column 139
[2] Patent: WO2006/44454, 2006, A1. Location in patent: Page/Page column 60-61
2-Chloro-4-Trifluoromethylbenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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