2-Pyridinesulfonamide,6-fluoro-(9CI)

Product Name: 2-Pyridinesulfonamide,6-fluoro-(9CI)
CAS No.: 124433-70-1
Chemical Name: 2-Pyridinesulfonamide,6-fluoro-(9CI)
Synonyms: 6-Fluoropyridine-2-sulfonamide;6-Fluoro-2-Pyridinesulfonamide;2-Pyridinesulfonamide,6-fluoro-;2-Pyridinesulfonamide,6-fluoro-(9CI)
CBNumber: CB71289463
Molecular Formula: C5H5FN2O2S
Formula Weight: 176.17
MOL File: 124433-70-1.mol

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2-Pyridinesulfonamide,6-fluoro-(9CI) Property

Boiling point:: 374.8±52.0 °C(Predicted)
Density: 1.521±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 9.00±0.60(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C5H5FN2O2S/c6-4-2-1-3-5(8-4)11(7,9)10/h1-3H,(H2,7,9,10)
InChIKey: WYYFSNSPYJRQLU-UHFFFAOYSA-N
SMILES: C1(S(N)(=O)=O)=NC(F)=CC=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B435570
Product name: 6-Fluoropyridine-2-sulfonamide
Packaging: 5mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: 0063AP
Product name: 6-Fluoropyridine-2-sulfonamide
Packaging: 100mg
Price: $143
Updated: 2021/12/16

AK Scientific

Product number: 0063AP
Product name: 6-Fluoropyridine-2-sulfonamide
Packaging: 250mg
Price: $200
Updated: 2021/12/16

Ambeed

Product number: A526293
Product name: 6-Fluoropyridine-2-sulfonamide
Purity: 95%
Packaging: 1g
Price: $230
Updated: 2021/12/16

Chemenu

Product number: CM294876
Product name: 6-Fluoropyridine-2-sulfonamide
Purity: 95%
Packaging: 1g
Price: $262
Updated: 2021/12/16

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2-Pyridinesulfonamide,6-fluoro-(9CI) Chemical Properties,Usage,Production

Synthesis

128583-07-3

124433-70-1

General procedure for the synthesis of 6-fluoro-2-pyridinesulfonamide from 6-fluoro-2-pyridinesulfonyl chloride: 6-fluoro-2-pyridinesulfonyl chloride (2.0875 g, 10.67 mmol) was dissolved in acetonitrile (50 mL) which was pre-cooled to 0 °C, and concentrated ammonia (70 mL, 539 mmol) was added slowly and dropwise. The reaction mixture was stirred at 0 °C for 30 min, then gradually warmed up to room temperature and continued stirring for 2 h. The reaction was completed by concentration reduction under reduced pressure. After the reaction was completed, some acetonitrile was removed by concentration under reduced pressure, and the residue was freeze-dried to obtain the target product, 6-fluoropyridine-2-sulfonamide, as a dark gray solid in 95% yield. The product was analyzed by LC/MS, ESI-MS m/z: 177.0 [M+H]+. 1H NMR (400 MHz, DMSO-d6) δ: 8.26 (q, J = 7.9 Hz, 1H), 7.88 (ddd, J = 7.5, 2.3, 0.6 Hz, 1H), 7.63 (s, 2H), 7.48 (ddd, J = 8.3, 2.4, 0.6 Hz). 2.4, 0.6 Hz, 1H).

References

[1] Patent: WO2018/42316, 2018, A1. Location in patent: Page/Page column 116; 117
[2] Patent: WO2011/94953, 2011, A1. Location in patent: Page/Page column 62-63
[3] Patent: WO2011/95576, 2011, A1. Location in patent: Page/Page column 62-63
[4] Patent: US2011/195979, 2011, A1. Location in patent: Page/Page column 34-35
[5] Patent: US2016/95858, 2016, A1. Location in patent: Paragraph 2135; 2136

2-Pyridinesulfonamide,6-fluoro-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Pyridinesulfonamide,6-fluoro-(9CI) Suppliers

China 34 Europe 1 United States 1 Global 36

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124433-70-1, 2-Pyridinesulfonamide,6-fluoro-(9CI)Related Search:

2-Pyridinesulfonamide,6-fluoro-(9CI)

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2-Pyridinesulfonamide,6-fluoro-

124433-70-1

C5H5FN2O2S

SULFONAMIDE