9H-Purin-6-amine,8-ethoxy-9-ethyl-(9CI)

Product Name: 9H-Purin-6-amine,8-ethoxy-9-ethyl-(9CI)
CAS No.: 634924-89-3
Chemical Name: 9H-Purin-6-amine,8-ethoxy-9-ethyl-(9CI)
Synonyms: ANR 94;ANR-94 >=98% (HPLC);ANR 94, 10 mM in DMSO;8-Ethoxy-9-ethyl-9H-purin-6-amine;9H-Purin-6-amine, 8-ethoxy-9-ethyl-;9H-Purin-6-amine,8-ethoxy-9-ethyl-(9CI)
CBNumber: CB71294320
Molecular Formula: C9H13N5O
Formula Weight: 207.23
MOL File: 634924-89-3.mol

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9H-Purin-6-amine,8-ethoxy-9-ethyl-(9CI) Property

Boiling point:: 394.4±45.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: Store at RT
solubility: DMSO: soluble1mg/mL, clear (warmed)
pka: 4.89±0.10(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Tocris

Product number: 3937
Product name: ANR94
Purity: ≥99%(HPLC)
Packaging: 50
Price: $744
Updated: 2021/12/16

Tocris

Product number: 3937
Product name: ANR94
Purity: ≥99%(HPLC)
Packaging: 10
Price: $189
Updated: 2021/12/16

TRC

Product number: A637248
Product name: ANR94
Packaging: 2.5mg
Price: $250
Updated: 2021/12/16

Usbiological

Product number: 254640
Product name: ANR 94
Packaging: 10mg
Price: $466
Updated: 2021/12/16

ApexBio Technology

Product number: B7540
Product name: ANR94
Packaging: 10mg
Price: $322
Updated: 2021/12/16

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9H-Purin-6-amine,8-ethoxy-9-ethyl-(9CI) Chemical Properties,Usage,Production

Uses

ANR 94 is an adenosine A2A receptor antagonist, which may have a potential therapeutic role in treating Parkinson’s disease.

Biological Activity

8-ethoxy-9-ethyladenine (anr 94) had been characterized in vitro as an adenosine receptor antagonist. its chemical structure had been shown [1]. anr 94 has shown high selectivity and affinity for the human adenosine a2a receptor subtype and high antiparkinsonian activity in unilaterally 6-hydroxydopamine (6-ohda)-lesioned rats [2]. the ki value of anr 94 to the adenosine a2a receptor is 46 nm [1].adenosine is deeply involved in the control of motor behaviour and substantial evidences [1].in chinese hamster ovary (cho) cells stably transfected with human recombinant adenosine receptors, anr 94 was more selective than anr 82 at the adenosine a2a receptor, with a ki value of 46 nm [1]. treatment with anr 94 (0.5 mg/kg i.p. for 7 days) significantly prevented 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (mptp)-induced degeneration of th-positive cells (p < 0.0005) [2].in rats, at a dose of 5 mg/kg i.p., anr 94 did not modify spontaneous motility, whereas at higher doses (10 or 15 mg/kg), it induced hypermotility. anr 94 at a dose of 1 mg/kg had a low efficacy on catalepsy, whereas 5 mg/kg was fully effective. in deeply cataleptic rats, anr 94 at a dose of 5 mg/kg i.p. during the 90-min testing period significantly reversed the catalepsy induced by 0.2 mg/kg of haloperidol. from 30-60 min, the effect of anr 94 was maximal. the anticataleptic effect of anr 94 had a long duration of over 150 min. in 6-ohda-lesioned rats, anr 94 significantly increased the number of contralateral rotations induced by l-dopa (3 mg/kg); this effect lasted up to 120-130 min [2].

storage

Store at RT

References

[1]. annalisa pinna, rosaria volpini, gloria cristalli, et al. new adenosine a2a receptor antagonists: actions on parkinson’s disease models. european journal of pharmacology, 2005, 512:157-164.
[2]. annalisa pinna, elisabetta tronci, nicoletta schintu, et al. a new ethyladenine antagonist of adenosine a2a receptors: behavioral and biochemical characterization as an antiparkinsonian drug. neuropharmacology, 2010, 58: 613-623.

9H-Purin-6-amine,8-ethoxy-9-ethyl-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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634924-89-3, 9H-Purin-6-amine,8-ethoxy-9-ethyl-(9CI)Related Search:

8-Ethoxy-9-ethyl-9H-purin-6-amine

ANR 94

9H-Purin-6-amine,8-ethoxy-9-ethyl-(9CI)

9H-Purin-6-amine, 8-ethoxy-9-ethyl-

ANR-94 >=98% (HPLC)

ANR 94, 10 mM in DMSO

634924-89-3

ETHOXY

ETHYL