ChemicalBook > CAS DataBase List > N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN

N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN

Product Name: N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN
CAS No.: 112525-72-1
Chemical Name: N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN
Synonyms: STK367969;Boc-DL-tryptophan;N-α-Boc-DL-Tryptophan;(tert-Butoxycarbonyl)tryptophan;N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN;N-(tert-Butoxycarbonyl)-DL-tryptophan >(tert-Butoxycarbonyl)tryptophan - [B92214];N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN USP/EP/BP;N-(tert-Butoxycarbonyl)-DL-tryptophan;3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoicaci
CBNumber: CB7129966
Molecular Formula: C16H20N2O4
Formula Weight: 304.34
MOL File: 112525-72-1.mol

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N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN Property

Melting point:: 131 °C(dec.)
Boiling point:: 535.7±45.0 °C(Predicted)
Density: 1.262±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: powder to crystal
pka: 4.00±0.10(Predicted)
color: White to Light yellow
optical activity: -0.5°(C=0.01 g/ml DMF)

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Safety

HS Code: 2933.99.8290

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4891
Product name: N-(tert-Butoxycarbonyl)-DL-tryptophan
Packaging: 1G
Price: $23
Updated: 2025/07/31

TCI Chemical

Product number: B4891
Product name: N-(tert-Butoxycarbonyl)-DL-tryptophan
Packaging: 5G
Price: $71
Updated: 2025/07/31

AK Scientific

Product number: 0899AP
Product name: Boc-DL-tryptophan
Packaging: 25g
Price: $81
Updated: 2021/12/16

Activate Scientific

Product number: AS103037
Product name: Boc-DL-tryptophan
Purity: 95%
Packaging: 25g
Price: $104
Updated: 2021/12/16

Activate Scientific

Product number: AS103037
Product name: Boc-DL-tryptophan
Purity: 95%
Packaging: 100g
Price: $271
Updated: 2021/12/16

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N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN Chemical Properties,Usage,Production

Synthesis

24424-99-5

54-12-6

5241-64-5

Step 3. General procedure for the preparation of BOC-D-tryptophan. To a solution of water (54 mL) containing NaOH (2.2 g, 55.0 mmol) was added DL-tryptophan (10.0 g, 49.0 mmol) and 1,4-dioxane (36 mL). Subsequently, di-tert-butyl dicarbonate (Boc2O, 10.7 g, 49.1 mmol) was added slowly and dropwise to the above mixture. The reaction mixture was stirred at room temperature for 24 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and the completion of the reaction was indicated by the unfolding of dichloromethane: methanol = 10:1 and an Rf value of 0.5. The reaction mixture was adjusted to pH 6.0 with solid citric acid and subsequently extracted with ethyl acetate (EtOAc, 30 mL x 3). The organic layers were combined, dried and concentrated to give a colorless oil. The residue was washed with petroleum ether (100 mL) and filtered, and the filter cake was further washed with petroleum ether and dried to give BOC-D-tryptophan (14.8 g, 99.0% yield) as a final white solid.

References

[1] Patent: WO2014/14937, 2014, A1. Location in patent: Paragraph 0125; 0128
[2] Patent: CN104876930, 2017, B. Location in patent: Paragraph 0054-0056
[3] Patent: US2010/297756, 2010, A1
[4] Chemistry - A European Journal, 2015, vol. 21, # 51, p. 18589 - 18593
[5] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 140 - 153

N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN Preparation Products And Raw materials

Raw materials

Preparation Products

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112525-72-1, N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHANRelated Search:

BOC-TRP-OSU BOC-L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID N-[(tert-Butoxy)carbonyl]-L-tryptophan BOC-D-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID BOC-TRP(BOC)-OH BOC-TRP-OME N-[(tert-Butoxy)carbonyl]-D-tryptophan BOC-TRP(FOR)-OH BOC-TRP(FOR)-OSU N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN BOC-D-TRP(FOR)-OH BOC-TRP-ONP BOC-L-TRP(FORMYL)-O-CH2-PHI-CH2-COOH BOC-TRYPTOPHAN NCA BOC-TRP-OBZL BOC-5-HYDROXY-L-TRYPTOPHAN ADPOC-TRP-OH BOC-TRP(MTS)-OH DCHA

N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN

Boc-DL-tryptophan

N-(tert-Butoxycarbonyl)-DL-tryptophan

N-α-Boc-DL-Tryptophan

3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid

N-(tert-Butoxycarbonyl)-DL-tryptophan &gt

3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoicaci

N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN USP/EP/BP

(tert-Butoxycarbonyl)tryptophan

STK367969

(tert-Butoxycarbonyl)tryptophan - [B92214]

112525-72-1