1-(2-CHLORO-ETHYL)-4-METHYL-PIPERAZINE
- Product Name
- 1-(2-CHLORO-ETHYL)-4-METHYL-PIPERAZINE
- CAS No.
- 5753-26-4
- Chemical Name
- 1-(2-CHLORO-ETHYL)-4-METHYL-PIPERAZINE
- Synonyms
- 1-(2-Chloroethyl)-4-Methylpiperazine dihydrochloride;AKOS BB-5271;1-(2-Chloroethyl);-4-methylpiperazine dihydrochloride;6-Piperazinecarboxamide,N,N-dimethyl-;1-(2-CHLORO-ETHYL)-4-METHYL-PIPERAZINE;1-(2-CHLOROETHYL)-4-METHYLPIPERAZINE 2HCL;1-(2-Chloroethyl)-4-methylpiperazine DiHCl;1-chloro-2-(4-methyl-1-piperazinyl)ethane dihydrochloride
- CBNumber
- CB7130638
- Molecular Formula
- C7H15ClN2
- Formula Weight
- 162.66
- MOL File
- 5753-26-4.mol
1-(2-CHLORO-ETHYL)-4-METHYL-PIPERAZINE Property
- Melting point:
- 300℃ (decomposition)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C984738
- Product name
- 1-(2-Chloroethyl)-4-methylpiperazinedihydrochloride
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FC117863
- Product name
- 1-(2-Chloroethyl)-4-methylpiperazine dihydrochloride
- Packaging
- 500mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- W7092
- Product name
- 1-(2-Chloroethyl)-4-methylpiperazinedihydrochloride
- Packaging
- 250mg
- Price
- $93
- Updated
- 2021/12/16
- Product number
- FC117863
- Product name
- 1-(2-Chloroethyl)-4-methylpiperazine dihydrochloride
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 062535
- Product name
- 1-(2-Chloroethyl)-4-methylpiperazine hydrochloride
- Packaging
- 250mg
- Price
- $32
- Updated
- 2021/12/16
1-(2-CHLORO-ETHYL)-4-METHYL-PIPERAZINE Chemical Properties,Usage,Production
Synthesis
109-01-3
107-04-0
5753-26-4
The general procedure for the synthesis of 1-(2-chloroethyl)-4-methylpiperazine dihydrochloride from N-methylpiperazine and 1-bromo-2-chloroethane was as follows: 10 mL of a 25% NaOH solution and 1 mL (9 mmol) of N-methylpiperazine were added sequentially to a dry reaction flask. The mixture was heated to 50 °C and then 1.8 mL (18 mmol) of 1-bromo-2-chloroethane was added slowly and dropwise with stirring. The reaction mixture was kept at 50 °C for 6 hours with stirring. After the reaction was completed, the mixture was cooled to room temperature. The reaction mixture was extracted with ethyl acetate (3 x 20 mL), the organic phases were combined, washed with saturated NaCl solution (20 mL), and then dried over anhydrous Na2SO4. The desiccant was removed by filtration and the filtrate was concentrated to dryness under reduced pressure. A small amount of ethanol/NaOH solution was added dropwise to the residue, and the mixture was shaken and placed in a refrigerator overnight. Finally, the mixture was concentrated to dryness under reduced pressure to give 0.43 g of white solid product in 23% yield. The melting point of the product was 227-230 °C.
References
[1] Patent: US2013/85140, 2013, A1. Location in patent: Paragraph 0064; 0065
1-(2-CHLORO-ETHYL)-4-METHYL-PIPERAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
1-(2-CHLORO-ETHYL)-4-METHYL-PIPERAZINE Suppliers
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