A 70874
- Product Name
- A 70874
- CAS No.
- 131449-37-1
- Chemical Name
- A 70874
- Synonyms
- A 70874;Nα-(tert-Butyloxycarbonyl)-L-Trp-N-[2-(4-hydroxyphenyl)ethenylcarbonyl]-L-Phe-methyl NH2;L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-N6-[3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]-L-lysyl-L-α-aspartyl-Nα-methyl-
- CBNumber
- CB71307590
- Molecular Formula
- C45H55N7O10
- Formula Weight
- 853.97
- MOL File
- 131449-37-1.mol
A 70874 Property
- Boiling point:
- 1214.5±65.0 °C(Predicted)
- Density
- 1.299±0.06 g/cm3(Predicted)
- pka
- 4.38±0.10(Predicted)
A 70874 Chemical Properties,Usage,Production
Description
A 70874 has high potency and selectivity for cholecystokinin (CCK) A receptors.
Uses
A-70874 is a tyrosine-free tetrapeptide analog of cholecystokinin (30-33) (CCK-4). A-70874 is an agonist that stimulates pancreatic amylase release and a partial agonist that stimulates pancreatic phosphoinositide decomposition. A-70874 has an IC50 of 4.9 nM for the guinea pig pancreatic CCK receptor. Cholecystokinin (CCK) receptors are divided into CCK-A (digestive tract) and CCK-B (brain). A-70874 has an affinity of 1.6 μM for the CCK-B/gastrin receptor[1].
References
[1] Lin CW, et al. Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol Pharmacol. 1991 Mar;39(3):346-51. PMID:1706470
A 70874 Preparation Products And Raw materials
Raw materials
Preparation Products
A 70874 Suppliers
- Tel
- 15002134094
- marketing@targetmol.cn
- Country
- China
- ProdList
- 29243
- Advantage
- 58