ChemicalBook > CAS DataBase List > SB 223412

SB 223412

Product Name
SB 223412
CAS No.
174636-32-9
Chemical Name
SB 223412
Synonyms
CS-1123;SB 223412;Talnetant (SB 223412);SB-223412; SB223412; SB 223412;3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide;(S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide;(S)-3-Hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide;3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide;3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide;(-)-3-Hydroxy-2-phenyl-N-[1(S)-phenylpropyl]quinoline-4-carboxamide
CBNumber
CB71333041
Molecular Formula
C25H22N2O2
Formula Weight
382.45
MOL File
174636-32-9.mol
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SB 223412 Property

Melting point:
125.1-126.2℃
Boiling point:
580.4±50.0 °C(Predicted)
Density 
1.212±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: soluble25mg/mL, clear
pka
6.70±0.50(Predicted)
form 
powder
color 
white to beige
optical activity
[α]/D -25 to -31°, c = 0.5 in methanol
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1165
Product name
Talnetant
Purity
≥98% (HPLC)
Packaging
5mg
Price
$146
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1165
Product name
Talnetant
Purity
≥98% (HPLC)
Packaging
25mg
Price
$578
Updated
2024/03/01
Cayman Chemical
Product number
29699
Product name
Talnetant
Packaging
100mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
29699
Product name
Talnetant
Packaging
500mg
Price
$317
Updated
2024/03/01
Cayman Chemical
Product number
29699
Product name
Talnetant
Packaging
250mg
Price
$169
Updated
2024/03/01
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SB 223412 Chemical Properties,Usage,Production

Description

Talnetant is an antagonist of the neurokinin-3 (NK3) receptor (Ki = 1 nM). It is selective for NK3 over NK1 and NK2 receptors (Kis = 144 and >100,000 nM, respectively, in CHO cells expressing recombinant human receptors). Talnetant inhibits calcium mobilization induced by neurokinin B in HEK293 cells expressing human NK3 receptors (IC50 = 16.6 nM). It inhibits contractions induced by the NK3 receptor agonist senktide in isolated rabbit iris sphincter muscle (pD2 = 9.1). Talnetant (5-20 mg/kg) reduces senktide-induced head shakes and tail whips in mice. It also inhibits senktide-induced wet-dog shakes, increases extracellular dopamine and norepinephrine in the medial prefrontal cortex, and attenuates haloperidol-induced increases in nucleus accumbens dopamine levels in guinea pigs.

Uses

Talnetant acts as a neurokinin 3 (NK3) receptor antagonist used as an antispychotic.

SB 223412 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB 223412 Suppliers

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View Lastest Price from SB 223412 manufacturers

Career Henan Chemical Co
Product
Talnetant 174636-32-9
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

174636-32-9, SB 223412Related Search:


  • SB 223412
  • 3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
  • (-)-(S)-N-(alpha-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxaMide
  • TALNETANT//SB223412//3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxaMide
  • SB-223412; SB223412; SB 223412
  • Talnetant (SB 223412)
  • CS-1123
  • Talnetant/(S)-3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
  • (-)-3-Hydroxy-2-phenyl-N-[1(S)-phenylpropyl]quinoline-4-carboxamide
  • (S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide
  • 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide
  • 3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide
  • 4-Quinolinecarboxamide, 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-
  • (S)-3-Hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
  • schizophrenia,SB223412,NK receptor,Inhibitor,hNK-2,Talnetant,Neurokinin Receptor,Tachykinin receptor,NK3 receptor,SB-223412,inhibit
  • 174636-32-9