ChemicalBook > CAS DataBase List > RG 7152
RG 7152
- Product Name
- RG 7152
- CAS No.
- 107813-63-8
- Chemical Name
- RG 7152
- Synonyms
- RG 7152;2-[3-[3-(1H-Tetrazol-5-yl)propoxy]phenoxymethyl]quinoline;2-({3-[3-(1H-1,2,3,4-tetrazol-5-yl)propoxy]phenoxy}methyl)quinoline
- CBNumber
- CB71334927
- Formula Weight
- 0
- MOL File
- 107813-63-8.mol
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RG 7152 Chemical Properties,Usage,Production
Uses
RG-7152 is a tetrazolyl-substituted leukotriene D4 receptor antagonist that can induce peroxisomal β-oxidation and peroxisome bifunctional enzymes (PBEs) in hepatocytes in various animal models. It has been shown to significantly increase PBE levels and β-oxidation activity in rat and mouse liver homogenates, while smaller effects were observed in guinea pigs and monkeys and no effect in dogs. In vitro studies have also shown that it can induce PBEs comparable to clofibric acid, indicating its potential as a peroxisome proliferator[1].
References
[1] Kelley M, et al. Induction of peroxisomal enzymes by a tetrazole-substituted 2-quinolinylmethoxy leukotriene D4 antagonist. Fundam Appl Toxicol. 1994 Aug;23(2):298-303. DOI:10.1006/faat.1994.1107
RG 7152 Preparation Products And Raw materials
Raw materials
Preparation Products
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