PCA 50941
- Product Name
- PCA 50941
- CAS No.
- 136941-85-0
- Chemical Name
- PCA 50941
- Synonyms
- PCA 50941;PCA-50941,PCA50941;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)ethyl] 5-[(tetrahydro-2H-pyran-2-yl)methyl] ester
- CBNumber
- CB71336572
- Molecular Formula
- C30H31N3O10S
- Formula Weight
- 625.64624
- MOL File
- 136941-85-0.mol
PCA 50941 Property
- Boiling point:
- 816.6±75.0 °C(Predicted)
- Density
- 1.387±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 2.60±0.70(Predicted)
PCA 50941 Chemical Properties,Usage,Production
Uses
PCA50941 is a 1,4-dihydropyridine derivative, used for treatment for cardiovascular disease.
in vivo
PCA50941 (10-120 μM) by intracoronary injection, causes smaller reductions of coronary blood flow (CBF) in goats. PCA50941 (10-300 μM/min) does not modify CBF nor the other hemodynamic variables recorded by i.v. infusions in 4 goats. Intravenous infusion of PCA50941 (100 microg/min) reverses the hemodynamic variables from the shock state to control values within 20 min in 5 of 6 animals[2].
References
[1] Montiel C, et al. Interactions between Ca2+, PCA50941 and Bay K 8644 in bovine chromaffin cells. Eur J Pharmacol. 1994 Aug 16;268(3):293-303. DOI:10.1016/0922-4106(94)90053-1
[2] Fernández N, et al. PCA50941, a new 1,4-dihydropyridine, reverses endothelin-induced cardiogenic shock in the anesthetized goat. Life Sci. 1998;62(21):1933-42. DOI:10.1016/s0024-3205(98)00162-3
PCA 50941 Preparation Products And Raw materials
Raw materials
Preparation Products
PCA 50941 Suppliers
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- Country
- South Korea
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