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danshenol A

Product Name
danshenol A
CAS No.
189308-08-5
Chemical Name
danshenol A
Synonyms
danshenol A;(1R,10S)-1,10-Dihydro-10-hydroxy-1,6-dimethyl-10-(2-oxopropyl)phenanthro[1,2-b]furan-11(2H)-one;Phenanthro[1,2-b]furan-11(2H)-one, 1,10-dihydro-10-hydroxy-1,6-dimethyl-10-(2-oxopropyl)-, (1R,10S)-
CBNumber
CB71339452
Molecular Formula
C21H20O4
Formula Weight
336.38
MOL File
189308-08-5.mol
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danshenol A Property

Boiling point:
571.5±50.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
powder
pka
10.86±0.40(Predicted)
color 
Red
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom
Product number
CFN92167
Product name
DanshenolA
Purity
≥98%
Packaging
5mg
Price
$536
Updated
2021/12/16
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danshenol A Chemical Properties,Usage,Production

Uses

Danshenol A, an abietane-type diterpenoid, is an aldose reductase (AR) inhibitor with an IC50 of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. Danshenol A can be used for atherosclerosis research[1][2][3][4].

Cytotoxicity

IC50 (μg/mL): 1.93 (HeLa), 2.22 (KB-3-1),3.97 (NCI-H460), 1.07 (PC3), 3.21(MCF-7), 0.63 (K562) (Wu et al. 2014)

in vivo

Danshenol A (0.3-3?mg/kg; p.o; daily; for 12 weeks) ameliorates blood pressure, cardiac injury, and myocardial collagen volume and improved cardiac function in SHR rats. Danshenol A repaires the structure/function of the mitochondria, alleviated oxidative stress in the myocardium[2].

Animal Model:Forty male spontaneously hypertensive rats (SHR) and eight male Wistar-Kyoto (WKY) rats at the age of 16 weeks[2]
Dosage:0.3?mg/kg, 1?mg/kg, 3?mg/kg
Administration:Orally administration; daily; for 12 weeks
Result:Ameliorated blood pressure, cardiac injury, and myocardial collagen volume and improved cardiac function.

References

[1] Wenwen Zhao, et al. Danshenol A inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1) mediated by NOX4 in endothelial cells. Sci Rep. 2017 Oct 11;7(1):12953. DOI:10.1038/s41598-017-13072-1
[2] Kai Chen, et al. Danshenol A Alleviates Hypertension-Induced Cardiac Remodeling by Ameliorating Mitochondrial Dysfunction and Suppressing Reactive Oxygen Species Production. Oxid Med Cell Longev. 2019 Sep 11;2019:2580409. DOI:10.1155/2019/2580409
[3] Y Tezuka, et al. Aldose reductase inhibitory constituents of the root of Salvia miltiorhiza Bunge. Chem Pharm Bull (Tokyo). 1997 Aug;45(8):1306-11. DOI:10.1248/cpb.45.1306
[4] Gang Xu, et al. Two new abietane diterpenoids from Salvia yunnanensis. Planta Med. 2006 Jan;72(1):84-6. DOI:10.1055/s-2005-873184

danshenol A Preparation Products And Raw materials

Raw materials

Preparation Products

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danshenol A Suppliers

CHINA 33 United States 3 Global 36
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
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028-81705658
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3003855609@qq.com
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China
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7778
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Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
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+86-27-84254680
Email
aileen@chemfaces.com
Country
China
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EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
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8447
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60
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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71826
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Shanghai ChengShao Biological Technology Co., Ltd.
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021-61847300 13341622919
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021-61847300
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shcss01@163.com
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China
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4808
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58
Shanghai SuperLan Chemcial Technique Centre
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0-2022843681 15618226720
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+86-21-51601218
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chaolaichem@foxmail.com
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China
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12475
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Chengdu Push Bio-Technology Co., Ltd.
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028-028-85370565-229-229 18080489829
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18080489829@163.com
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China
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8250
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Shanghai Jizhi Biochemical Technology Co. Ltd.
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4009004166/18616739031 18616739031
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3007523370@qq.com
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China
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52687
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58
Nanjing Digger Medical Technology Co. Ltd.
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025-025-51191215 18013836722
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025-51191215
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2399235533@qq.com
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China
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4933
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Zhejiang Lianshuo Biotechnology Co., Ltd.
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18616526224
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lianshuo@vip.126.com
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China
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9607
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189308-08-5, danshenol ARelated Search:


  • danshenol A
  • (1R,10S)-1,10-Dihydro-10-hydroxy-1,6-dimethyl-10-(2-oxopropyl)phenanthro[1,2-b]furan-11(2H)-one
  • Phenanthro[1,2-b]furan-11(2H)-one, 1,10-dihydro-10-hydroxy-1,6-dimethyl-10-(2-oxopropyl)-, (1R,10S)-
  • 189308-08-5