mebikar

Product Name: mebikar
CAS No.: 10095-06-4
Chemical Name: mebikar
Synonyms: mebikar;Mebicar;Mebican;Temgicoluril;Imidazo[4,5-d]im;Tetramethylglycoluril;Mebicarum/TETRAMETHYLTETRAAZABICYCLOOCTANDION;4,5-(1,3-Dimethylureylene)-1,3-dimethylimidazolidine-2-one;2,4,6,8-Tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]-3,7-oxandione;1,3,4,6-Tetramethyl-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione
CBNumber: CB71344551
Molecular Formula: C8H14N4O2
Formula Weight: 198.22
MOL File: 10095-06-4.mol

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mebikar Property

Melting point:: 226 - 229?C
Boiling point:: 362.2±42.0 °C(Predicted)
Density: 1.237±0.06 g/cm3(Predicted)
storage temp.: Refrigerator, under inert atmosphere
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: -0.49±0.20(Predicted)
color: White to Off-White
InChI: InChI=1S/C8H14N4O2/c1-9-5-6(11(3)7(9)13)12(4)8(14)10(5)2/h5-6H,1-4H3
InChIKey: XIUUSFJTJXFNGH-UHFFFAOYSA-N
SMILES: CN1C(N(C2N(C(N(C21)C)=O)C)C)=O

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: T889843
Product name: Tetrahydro-1,3,4,6-tetramethylimidazo(4,5-d)imidazole-2,5(1H,3H)-dione
Packaging: 200mg
Price: $220
Updated: 2021/12/16

Matrix Scientific

Product number: 064483
Product name: 1,3,4,6-Tetramethyltetrahydroimidazo[4,5-d]-imidazole-2,5(1H,3H)-dione
Packaging: 500mg
Price: $315
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0015373
Product name: MEBIKAR
Purity: 95.00%
Packaging: 0.5G
Price: $396
Updated: 2021/12/16

AK Scientific

Product number: 7296AC
Product name: 1,3,4,6-Tetramethyltetrahydroimidazo[4,5-d]-imidazole-2,5(1H,3H)-dione
Packaging: 500mg
Price: $475
Updated: 2021/12/16

Aronis compounds

Product number: m07140
Product name: 1,3,4,6-tetramethyltetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione
Packaging: 1mg
Price: $12
Updated: 2021/12/16

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mebikar Chemical Properties,Usage,Production

Uses

Temgicoluril (Tetramethylglycoluril) is an orally active antianxiety and antidepressant. Temgicoluril acts on GABA receptors to enhance GABA neurotransmission[1][2].

Definition

ChEBI: Mebicar is an imidazolidinone.

in vivo

Temgicoluril (10 mg/kg; Oral gavage; 3 weeks) has a preventive effect on neurobehavioral and immunological disruptions caused by intermittent unpredictable stress in mice^[2].

Animal Model:	Intermittent unpredictable stress (IUS) treated seven week-old Balb/cByJ mice^[2]
Dosage:	10 mg/kg
Administration:	Oral gavage (i.g.); 3 weeks
Result:	Recovered rapidly from anxiety-like behavior induced by the multiplexed stress compared with untreated mice. Did not prevent the decrease of brain-derived neurotropic factor by IUS exposure. Prevented elevation of serum corticosterone and secretion of proinflammatory cytokines from splenocytes due to IUS exposure.

References

[1] Val'dman AV, Zaikonnikova IV, Kozlovskaia MM, Zimakova IE. Izuchenie osobennoste? spektra psikhotropnogo de?stviia mebikara [Characteristics of the psychotropic spectrum of action of mebicar]. Biull Eksp Biol Med. 1980 May;89(5):568-70. Russian. PMID:6104993
[2] Kim CY, et al. Preventive Effect of Mebicar and Ginsenoside Rg1 on Neurobehavioral and Immunological Disruptions Caused by Intermittent Unpredictable Stress in Mice. Neuroimmunomodulation. 2018;25(1):49-58. DOI:10.1159/000489634

mebikar Preparation Products And Raw materials

Raw materials

Preparation Products

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mebikar Suppliers

China 40 India 1 Russia 1 South Korea 1 United States 6 Global 49

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View Lastest Price from mebikar manufacturers

Hebei Dangtong Import and export Co LTD

Product: mebikar 10095-06-4
Price: US $72.00-68.00/Grams
Min. Order: 10Grams
Purity: 99.99%
Supply Ability: 100Tons
Release date: 2023-03-17

Shaanxi Dideu New Materials Co. Ltd

Product: mebikar 10095-06-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 95.0%
Supply Ability: 10000KGS
Release date: 2024-11-19

10095-06-4, mebikarRelated Search:

Tetramethylol acetylenediurea HEXAHYDRO-2,6-BIS(2,2,6,6-TETRAMETHYL-4-PIPERIDINYL)-1H,4H,5H,8H-2,3A,4A,6,7A,8A-HEXAAZACYCLOPENTA[DEF]FLUORENE-4,8-DIONE 1,3,4,6-Tetrakis(methoxymethyl)glycoluril CUCURBITURIL 1,3,4,6-TETRAKIS(BUTOXYMETHYL)GLYCOLURIL, TECH. N,N',N'',N'''-Tetraacetylglycoluril mebikar

mebikar

2,4,6,8-Tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]-3,7-oxandione

3a,4,6,6a-Tetrahydro-1,3,4,6-tetramethylimidazo[4,5-d]imidazole-2,5(1H,3H)-dione

4,5-(1,3-Dimethylureylene)-1,3-dimethylimidazolidine-2-one

Mebicar

1,3,4,6-tetramethyl-3a,6a-dihydroimidazo[4,5-d]imidazole-2,5-dione

1,3,4,6-tetramethyl-3a,6a-dihydroimidazo[4,5-d]imidazole-2,5-quinone

1,3,4,6-Tetramethyl-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione

2,4,6,8-Tetraazabicyclo[3.3.0]octane-3,7-dione, 2,4,6,8-tetramethyl-

2,4,6,8-Tetramethyl-2,4,6,8-tetraazobicyclo(3.3.0)octane-3,7-dione

2,4,6,8-Tetramethyl-2,4,6,8-tetraazobizykl(3,3,0)oktandion-3,7 [German]

Imidazo[4,5-d]im

Tetrahydro-1,3,4,6-tetramethylimidazo(4,5-d)imidazole-2,5(1H,3H)-dione

2,4,6,8-Тetramethyl-2,4,6,8,tetraazabycyclo[3.3.0] octane- 3,7-dione, Mebicar

Imidazo[4,5-d]imidazole-2,5(1H,3H)-dione, tetrahydro-1,3,4,6-tetramethyl-

Temgicoluril

Tetramethylglycoluril

Mebicarum/TETRAMETHYLTETRAAZABICYCLOOCTANDION

Mebican

inhibit,Inhibitor,γ-Aminobutyric acid Receptor,Mebicar,Temgicoluril,Gamma-aminobutyric acid Receptor,GABA Receptor

Imidazo[4,5-d]imidazole-2,5(1H,3H)-dione,tetrahydro-1,3,4,6-tetramet

10095-06-4